[HTML][HTML] Extracellular matrix requirements for gastrointestinal organoid cultures
Organoids are a new class of biological model systems that have garnered significant
interest in the life sciences. When provided with the proper 3D matrix and biochemical …
interest in the life sciences. When provided with the proper 3D matrix and biochemical …
Primary cell-derived intestinal models: recapitulating physiology
The development of physiologically relevant intestinal models fueled by breakthroughs in
primary cell-culture methods has enabled successful recapitulation of key features of …
primary cell-culture methods has enabled successful recapitulation of key features of …
A fully automated high-throughput workflow for 3D-based chemical screening in human midbrain organoids
H Renner, M Grabos, KJ Becker, TE Kagermeier, J Wu… - elife, 2020 - elifesciences.org
Three-dimensional (3D) culture systems have fueled hopes to bring about the next
generation of more physiologically relevant high-throughput screens (HTS). However …
generation of more physiologically relevant high-throughput screens (HTS). However …
The effect of thiol structure on allyl sulfide photodegradable hydrogels and their application as a degradable scaffold for organoid passaging
Intestinal organoids are useful in vitro models for basic and translational studies aimed at
understanding and treating disease. However, their routine culture relies on animal‐derived …
understanding and treating disease. However, their routine culture relies on animal‐derived …
Advancing drug discovery for neurological disorders using iPSC-derived neural organoids
G Costamagna, GP Comi, S Corti - International Journal of Molecular …, 2021 - mdpi.com
In the last decade, different research groups in the academic setting have developed
induced pluripotent stem cell-based protocols to generate three-dimensional, multicellular …
induced pluripotent stem cell-based protocols to generate three-dimensional, multicellular …
Intestinal models for personalized medicine: from conventional models to microfluidic primary intestine-on-a-chip
XG Li, M Chen, S Zhao, X Wang - Stem Cell Reviews and Reports, 2021 - Springer
Intestinal dysfunction is frequently driven by abnormalities of specific genes, microbiota, or
microenvironmental factors, which usually differ across individuals, as do intestinal …
microenvironmental factors, which usually differ across individuals, as do intestinal …
Research progress, challenges, and breakthroughs of organoids as disease models
Y Huang, Z Huang, Z Tang, Y Chen… - Frontiers in Cell and …, 2021 - frontiersin.org
Traditional cell lines and xenograft models have been widely recognized and used in
research. As a new research model, organoids have made significant progress and …
research. As a new research model, organoids have made significant progress and …
Intestinal organoids: A new paradigm for engineering intestinal epithelium in vitro
In recent years, the advent of intestinal organoid culture systems has revolutionized in vitro
studies of the small intestine epithelium. Intestinal organoids are derived from self …
studies of the small intestine epithelium. Intestinal organoids are derived from self …
Human microphysiological models of intestinal tissue and gut microbiome
The gastrointestinal (GI) tract is a complex system responsible for nutrient absorption,
digestion, secretion, and elimination of waste products that also hosts immune surveillance …
digestion, secretion, and elimination of waste products that also hosts immune surveillance …
3D printing of sacrificial thioester elastomers using digital light processing for templating 3D organoid structures in soft biomatrices
Biofabrication allows for the templating of structural features in materials on cellularly-
relevant size scales, enabling the generation of tissue-like structures with controlled form …
relevant size scales, enabling the generation of tissue-like structures with controlled form …