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Naturally engineered maturation of cardiomyocytes
Ischemic heart disease remains one of the most prominent causes of mortalities worldwide
with heart transplantation being the gold-standard treatment option. However, due to the …
with heart transplantation being the gold-standard treatment option. However, due to the …
Maturing human pluripotent stem cell-derived cardiomyocytes in human engineered cardiac tissues
NT Feric, M Radisic - Advanced drug delivery reviews, 2016 - Elsevier
Engineering functional human cardiac tissue that mimics the native adult morphological and
functional phenotype has been a long held objective. In the last 5 years, the field of cardiac …
functional phenotype has been a long held objective. In the last 5 years, the field of cardiac …
[HTML][HTML] A platform for generation of chamber-specific cardiac tissues and disease modeling
Tissue engineering using cardiomyocytes derived from human pluripotent stem cells holds a
promise to revolutionize drug discovery, but only if limitations related to cardiac chamber …
promise to revolutionize drug discovery, but only if limitations related to cardiac chamber …
Functional maturation of human pluripotent stem cell derived cardiomyocytes in vitro–correlation between contraction force and electrophysiology
Cardiomyocytes from human pluripotent stem cells (hPSC-CM) have many potential
applications in disease modelling and drug target discovery but their phenotypic similarity to …
applications in disease modelling and drug target discovery but their phenotypic similarity to …
Structure, function and clinical relevance of the cardiac conduction system, including the atrioventricular ring and outflow tract tissues
It is now over 100years since the discovery of the cardiac conduction system, consisting of
three main parts, the sinus node, the atrioventricular node and the His–Purkinje system. The …
three main parts, the sinus node, the atrioventricular node and the His–Purkinje system. The …
Induced pluripotent stem cell-derived cardiomyocyte in vitro models: benchmarking progress and ongoing challenges
Recent innovations in differentiating cardiomyocytes from human induced pluripotent stem
cells (hiPSCs) have unlocked a viable path to creating in vitro cardiac models. Currently …
cells (hiPSCs) have unlocked a viable path to creating in vitro cardiac models. Currently …
The hyperpolarization-activated cyclic nucleotide–gated channels: from biophysics to pharmacology of a unique family of ion channels
Hyperpolarization-activated, cyclic nucleotide–gated (HCN) channels are important
members of the voltage-gated pore loop channels family. They show unique features: they …
members of the voltage-gated pore loop channels family. They show unique features: they …
Towards chamber specific heart-on-a-chip for drug testing applications
Modeling of human organs has long been a task for scientists in order to lower the costs of
therapeutic development and understand the pathological onset of human disease. For …
therapeutic development and understand the pathological onset of human disease. For …
Human induced pluripotent stem cell–derived engineered heart tissue as a sensitive test system for QT prolongation and arrhythmic triggers
Background: Cardiac repolarization abnormalities in drug-induced and genetic long-QT
syndrome may lead to afterdepolarizations and life-threatening ventricular arrhythmias …
syndrome may lead to afterdepolarizations and life-threatening ventricular arrhythmias …
High Throughput Measurement of Ca++ Dynamics in Human Stem Cell-Derived Cardiomyocytes by Kinetic Image Cytometery: A Cardiac Risk Assessment …
HR Lu, R Whittaker, JH Price, R Vega… - Toxicological …, 2015 - academic.oup.com
Human induced pluripotent stem cell-derived cardiomyocytes (hiPS-CMs) are emerging as a
powerful in vitro model for cardiac safety assessment which may allow for better …
powerful in vitro model for cardiac safety assessment which may allow for better …