Mechanisms of ketamine action as an antidepressant
Clinical studies have demonstrated that a single sub-anesthetic dose of the dissociative
anesthetic ketamine induces rapid and sustained antidepressant actions. Although this …
anesthetic ketamine induces rapid and sustained antidepressant actions. Although this …
Hippocampal GABAergic inhibitory interneurons
KA Pelkey, R Chittajallu, MT Craig… - Physiological …, 2017 - journals.physiology.org
In the hippocampus GABAergic local circuit inhibitory interneurons represent only~ 10–15%
of the total neuronal population; however, their remarkable anatomical and physiological …
of the total neuronal population; however, their remarkable anatomical and physiological …
NMDAR inhibition-independent antidepressant actions of ketamine metabolites
Major depressive disorder affects around 16 per cent of the world population at some point
in their lives. Despite the availability of numerous monoaminergic-based antidepressants …
in their lives. Despite the availability of numerous monoaminergic-based antidepressants …
Synaptic mechanisms of synchronized gamma oscillations in inhibitory interneuron networks
Gamma frequency oscillations are thought to provide a temporal structure for information
processing in the brain. They contribute to cognitive functions, such as memory formation …
processing in the brain. They contribute to cognitive functions, such as memory formation …
Hyperpolarization-activated cation channels: from genes to function
M Biel, C Wahl-Schott, S Michalakis… - Physiological …, 2009 - journals.physiology.org
Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels comprise a small
subfamily of proteins within the superfamily of pore-loop cation channels. In mammals, the …
subfamily of proteins within the superfamily of pore-loop cation channels. In mammals, the …
Neuronal dynamics and neuropsychiatric disorders: toward a translational paradigm for dysfunctional large-scale networks
In recent years, numerous studies have tested the relevance of neural oscillations in
neuropsychiatric conditions, highlighting the potential role of changes in temporal …
neuropsychiatric conditions, highlighting the potential role of changes in temporal …
An oscillatory hierarchy controlling neuronal excitability and stimulus processing in the auditory cortex
EEG oscillations are hypothesized to reflect cyclical variations in the neuronal excitability,
with particular frequency bands reflecting differing spatial scales of brain operation …
with particular frequency bands reflecting differing spatial scales of brain operation …
Convergent mechanisms underlying rapid antidepressant action
Traditional pharmacological treatments for depression have a delayed therapeutic onset,
ranging from several weeks to months, and there is a high percentage of individuals who …
ranging from several weeks to months, and there is a high percentage of individuals who …
[HTML][HTML] Feedback inhibition enables theta-nested gamma oscillations and grid firing fields
Cortical circuits are thought to multiplex firing rate codes with temporal codes that rely on
oscillatory network activity, but the circuit mechanisms that combine these coding schemes …
oscillatory network activity, but the circuit mechanisms that combine these coding schemes …
Tactile spatial attention enhances gamma-band activity in somatosensory cortex and reduces low-frequency activity in parieto-occipital areas
We investigated the effects of spatial-selective attention on oscillatory neuronal dynamics in
a tactile delayed-match-to-sample task. Whole-head magnetoencephalography was …
a tactile delayed-match-to-sample task. Whole-head magnetoencephalography was …