Experiments of nature have revealed the peculiar importance of the G-protein–coupled
receptor, CC chemokine receptor type 5 (CCR5), in human disease since ancient times. The …

Chemokine receptors comprise a large family of seven transmembrane domain G protein-
coupled receptors differentially expressed in diverse cell types. Biological activities have …

Objective Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is
now a global pandemic. Emerging results indicate a dysregulated immune response. Given …

Chemokines are critical mediators of cell migration during routine immune surveillance,
inflammation, and development. Chemokines bind to G protein–coupled receptors and …

G-protein-coupled receptors (GPCRs) are activated by a diverse range of ligands, from large
proteins and proteases to small peptides, metabolites, neurotransmitters and ions. They are …

G protein‐coupled chemokine receptors and their peptidergic ligands are interesting
therapeutic targets due to their involvement in various immune‐related diseases, including …

HIV-1 entry into CD4+ cells requires the sequential interactions of the viral envelope
glycoproteins with CD4 and a coreceptor such as the chemokine receptors CCR5 and …

This review focuses on the construction and application of structural chemokine receptor
models for the elucidation of molecular determinants of chemokine receptor modulation and …

Plants have been proposed as an attractive alternative for pharmaceutical protein
production to current mammalian or microbial cell‐based systems. Eukaryotic protein …

Human immunodeficiency virus (HIV) exploits cell surface receptors to attach to and gain
entry into cells. The HIV envelope spike glycoprotein on the surface of virus particles binds …