New insights into activation and function of the AMPK
The classical role of AMP-activated protein kinase (AMPK) is as a cellular energy sensor
activated by falling energy status, signalled by increases in AMP to ATP and ADP to ATP …
activated by falling energy status, signalled by increases in AMP to ATP and ADP to ATP …
The PI3K–AKT network at the interface of oncogenic signalling and cancer metabolism
The altered metabolic programme of cancer cells facilitates their cell-autonomous
proliferation and survival. In normal cells, signal transduction pathways control core cellular …
proliferation and survival. In normal cells, signal transduction pathways control core cellular …
AMPK: guardian of metabolism and mitochondrial homeostasis
Cells constantly adapt their metabolism to meet their energy needs and respond to nutrient
availability. Eukaryotes have evolved a very sophisticated system to sense low cellular ATP …
availability. Eukaryotes have evolved a very sophisticated system to sense low cellular ATP …
AMPK: mechanisms of cellular energy sensing and restoration of metabolic balance
D Garcia, RJ Shaw - Molecular cell, 2017 - cell.com
AMPK is a highly conserved master regulator of metabolism, which restores energy balance
during metabolic stress both at the cellular and physiological levels. The identification of …
during metabolic stress both at the cellular and physiological levels. The identification of …
Redox regulation of immunometabolism
J Muri, M Kopf - Nature Reviews Immunology, 2021 - nature.com
Metabolic pathways and redox reactions are at the core of life. In the past decade (s),
numerous discoveries have shed light on how metabolic pathways determine the cellular …
numerous discoveries have shed light on how metabolic pathways determine the cellular …
AMPK and TOR: the yin and yang of cellular nutrient sensing and growth control
The AMPK (AMP-activated protein kinase) and TOR (target-of-rapamycin) pathways are
interlinked, opposing signaling pathways involved in sensing availability of nutrients and …
interlinked, opposing signaling pathways involved in sensing availability of nutrients and …
The MAPK and AMPK signalings: interplay and implication in targeted cancer therapy
J Yuan, X Dong, J Yap, J Hu - Journal of hematology & oncology, 2020 - Springer
Cancer is characterized as a complex disease caused by coordinated alterations of multiple
signaling pathways. The Ras/RAF/MEK/ERK (MAPK) signaling is one of the best-defined …
signaling pathways. The Ras/RAF/MEK/ERK (MAPK) signaling is one of the best-defined …
Regulation and function of AMPK in physiology and diseases
SM Jeon - Experimental & molecular medicine, 2016 - nature.com
adenosine monophosphate (AMP)-activated protein kinase (AMPK) is an evolutionarily
conserved serine/threonine kinase that was originally identified as the key player in …
conserved serine/threonine kinase that was originally identified as the key player in …
Akt in cancer: Mediator and more
Akt is a serine/threonine kinase and it participates in the key role of the PI3K signaling
pathway. The Akt can be activated by a wide range of growth signals and the biochemical …
pathway. The Akt can be activated by a wide range of growth signals and the biochemical …
AMP-activated protein kinase: the current landscape for drug development
Since the discovery of AMP-activated protein kinase (AMPK) as a central regulator of energy
homeostasis, many exciting insights into its structure, regulation and physiological roles …
homeostasis, many exciting insights into its structure, regulation and physiological roles …