Hypertension and cardiomyopathy associated with chronic kidney disease: epidemiology, pathogenesis and treatment considerations

JP Law, L Pickup, D Pavlovic, JN Townend… - Journal of Human …, 2023 - nature.com
Chronic kidney disease (CKD) is a complex condition with a prevalence of 10–15%
worldwide. An inverse-graded relationship exists between cardiovascular events and …

Dialysis-induced cardiovascular and multiorgan morbidity

B Canaud, JP Kooman, NM Selby, MW Taal… - Kidney international …, 2020 - Elsevier
Hemodialysis has saved many lives, albeit with significant residual mortality. Although poor
outcomes may reflect advanced age and comorbid conditions, hemodialysis per se may …

A Personalized Approach to Chronic Kidney Disease and Cardiovascular Disease: JACC Review Topic of the Week

AC Lai, SW Bienstock, R Sharma, K Skorecki… - Journal of the American …, 2021 - jacc.org
Cardiovascular disease is the most common cause of death in patients with end-stage renal
disease (ESRD). The initiation of dialysis for treatment of ESRD exacerbates chronic …

High oxalate concentrations correlate with increased risk for sudden cardiac death in dialysis patients

A Pfau, T Ermer, SG Coca, MC Tio… - Journal of the …, 2021 - journals.lww.com
Background The clinical significance of accumulating toxic terminal metabolites such as
oxalate in patients with kidney failure is not well understood. Methods To evaluate serum …

Multitargeted interventions to reduce dialysis-induced systemic stress

B Canaud, MP Stephens, M Nikam, M Etter… - Clinical Kidney …, 2021 - academic.oup.com
Hemodialysis (HD) is a life-sustaining therapy as well as an intermittent and repetitive stress
condition for the patient. In ridding the blood of unwanted substances and excess fluid from …

Clinical potential of targeting fibroblast growth Factor‐23 and αKlotho in the treatment of uremic cardiomyopathy

JP Law, AM Price, L Pickup… - Journal of the …, 2020 - Am Heart Assoc
Chronic kidney disease is highly prevalent, affecting 10% to 15% of the adult population
worldwide and is associated with increased cardiovascular morbidity and mortality. As …

Arrhythmias and sudden cardiac death in end stage renal disease: epidemiology, risk factors, and management

R Samanta, C Chan, VS Chauhan - Canadian Journal of Cardiology, 2019 - Elsevier
Patients with end-stage renal disease (ESRD) are predisposed to heart rhythm disorders
resulting in significant morbidity and mortality. Bradyarrhythmia appears to be more …

Training convolutional neural networks on simulated photoplethysmography data: application to bradycardia and tachycardia detection

A Sološenko, B Paliakaitė, V Marozas… - Frontiers in …, 2022 - frontiersin.org
Objective: To develop a method for detection of bradycardia and ventricular tachycardia
using the photoplethysmogram (PPG). Approach: The detector is based on a dual-branch …

[HTML][HTML] Modeling of artifacts in the wrist photoplethysmogram: Application to the detection of life-threatening arrhythmias

B Paliakaitė, A Petrėnas, A Sološenko… - … Signal Processing and …, 2021 - Elsevier
Objective A model for simulating motion-induced artifacts in the wrist photoplethysmogram
(PPG) is proposed for the purpose to improve realism of PPG models. Methods The …

Hypocalcemia-induced slowing of human sinus node pacemaking

A Loewe, Y Lutz, D Nairn, A Fabbri, N Nagy, N Toth… - Biophysical …, 2019 - cell.com
Each heartbeat is initiated by cyclic spontaneous depolarization of cardiomyocytes in the
sinus node forming the primary natural pacemaker. In patients with end-stage renal disease …