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Reactive oxygen species, toxicity, oxidative stress, and antioxidants: Chronic diseases and aging
A physiological level of oxygen/nitrogen free radicals and non-radical reactive species
(collectively known as ROS/RNS) is termed oxidative eustress or “good stress” and is …
(collectively known as ROS/RNS) is termed oxidative eustress or “good stress” and is …
Oxidative stress in cancer cell metabolism
Reactive oxygen species (ROS) are important in regulating normal cellular processes
whereas deregulated ROS leads to the development of a diseased state in humans …
whereas deregulated ROS leads to the development of a diseased state in humans …
Chalcone derivatives: role in anticancer therapy
Y Ouyang, J Li, X Chen, X Fu, S Sun, Q Wu - Biomolecules, 2021 - mdpi.com
Chalcones (1, 3-diaryl-2-propen-1-ones) are precursors for flavonoids and isoflavonoids,
which are common simple chemical scaffolds found in many naturally occurring compounds …
which are common simple chemical scaffolds found in many naturally occurring compounds …
The multifaceted role of reactive oxygen species in tumorigenesis
Redox homeostasis is an essential requirement of the biological systems for performing
various normal cellular functions including cellular growth, differentiation, senescence …
various normal cellular functions including cellular growth, differentiation, senescence …
ROS signalling in the biology of cancer
JN Moloney, TG Cotter - Seminars in cell & developmental biology, 2018 - Elsevier
Increased reactive oxygen species (ROS) production has been detected in various cancers
and has been shown to have several roles, for example, they can activate pro-tumourigenic …
and has been shown to have several roles, for example, they can activate pro-tumourigenic …
Reactive oxygen species and cancer paradox: to promote or to suppress?
Reactive oxygen species (ROS), a group of highly reactive ions and molecules, are
increasingly being appreciated as powerful signaling molecules involved in the regulation of …
increasingly being appreciated as powerful signaling molecules involved in the regulation of …
ROS in cancer: the burning question
An unanswered question in human health is whether antioxidation prevents or promotes
cancer. Antioxidation has historically been viewed as chemopreventive, but emerging …
cancer. Antioxidation has historically been viewed as chemopreventive, but emerging …
The two faces of reactive oxygen species in cancer
Reactive oxygen species (ROS), now appreciated for their cellular signaling capabilities,
have a dual role in cancer. On the one hand, ROS can promote protumorigenic signaling …
have a dual role in cancer. On the one hand, ROS can promote protumorigenic signaling …
Kaempferol induces ROS-dependent apoptosis in pancreatic cancer cells via TGM2-mediated Akt/mTOR signaling
F Wang, L Wang, C Qu, L Chen, Y Geng, C Cheng… - BMC cancer, 2021 - Springer
Background Kaempferol, a natural flavonoid, exhibits anticancer properties by scavenging
reactive oxygen species (ROS). However, increasing evidence has demonstrated that …
reactive oxygen species (ROS). However, increasing evidence has demonstrated that …
Targeting the STAT3 signaling pathway in cancer: role of synthetic and natural inhibitors
Signal transducers and activators of transcription (STATs) comprise a family of cytoplasmic
transcription factors that mediate intracellular signaling that is usually generated at cell …
transcription factors that mediate intracellular signaling that is usually generated at cell …