Vancomycin is a glycopeptide antibiotic used for the treatment of Gram-positive bacterial
infections. Traditionally, it has been used as a drug of last resort; however, clinical isolates of …

Staphylococcus aureus can exemplify better than any other human pathogen the adaptive
evolution of bacteria in the antibiotic era, as it has demonstrated a unique ability to quickly …

Natural products containing carbon-phosphorus bonds (phosphonic and phosphinic acids)
have found widespread use in medicine and agriculture. Recent years have seen a …

Background: The advancing antimicrobial drug resistance in Gram-positive cocci
complicates the selection of appropriate therapy. The re-evaluation of older antibiotics may …

The aim of our study was to trace the dynamic changes of hospital-associated methicillin-
resistant Staphylococcus aureus (HA-MRSA) lineages in Italy, comparing the genotypic …

The biosynthetic pathway of the clinically important antibiotic fosfomycin uses enzymes that
catalyse reactions without precedent in biology. Among these is hydroxypropylphosphonic …

Staphylococcus aureus with resistance to glycopeptide antibiotics has been considered to
be a rare cause of clinically relevant infections. A review of the current literature shows that …

Abstract (S)-2-hydroxypropylphosphonate ((S)-2-HPP) epoxidase (HppE) is a mononuclear
non-haem-iron-dependent enzyme,, responsible for the final step in the biosynthesis of the …

The most frequent agents of severe bacterial infections and their antibiotic susceptibility
patterns were determined in patients admitted to 45 Italian hospitals over the years 2002 …

Hydroxypropylphosphonic acid epoxidase (HppE) is an unusual mononuclear iron enzyme
that uses dioxygen to catalyze the oxidative epoxidation of (S)-2-hydroxypropylphosphonic …