Pancreatic β-cell dysfunction plays an important role in the pathogenesis of both type 1 and
type 2 diabetes. Insulin, which is produced in β-cells, is a critical regulator of metabolism …

Pancreas oganogenesis comprises a coordinated and highly complex interplay of signaling
events and transcriptional networks that guide a step‐wise process of organ development …

The major focus of this Review is on the mechanisms of islet β cell failure in the
pathogenesis of obesity-associated type 2 diabetes (T2D). As this demise occurs within the …

Diabetes causes pancreatic β cell failure through hyperglycemia-induced oxidative stress,
or" glucose toxicity." We show that the forkhead protein FoxO1 protects β cells against …

The pancreatic duodenum homeobox-1 (PDX-1) is a transcription factor encoded by a Hox-
like homeodomain gene that plays a crucial role in pancreatic development, β-cell …

MicroRNAs (miRNAs) were shown to be important for pancreas development, yet their roles
in differentiated β‐cells remain unclear. Here, we show that miRNA inactivation in β‐cells of …

Pancreas morphogenesis and cell differentiation are highly conserved among vertebrates
during fetal development. The pancreas develops through simple budlike structures on the …

To date, more than 30 genes have been linked to monogenic diabetes. Candidate gene and
genome-wide association studies have identified> 50 susceptibility loci for common type 1 …

The pancreas is an essential endoderm-derived organ that ensures nutrient metabolism via
its endocrine and exocrine functions. Here we review the essential processes governing the …

The major forms of diabetes are characterized by pancreatic islet β-cell dysfunction and
decreased β-cell numbers, raising hope for cell replacement therapy. Although human islet …