Not all adaptive immune systems use the immunoglobulin fold as the basis for specific
recognition molecules: sea lampreys, for example, have evolved an adaptive immune …

In recent years new nucleic acid and protein‐based combinatorial molecules have attracted
the attention of researchers working in various areas of science, ranging from medicine to …

We present a strategy for generating and analyzing comprehensive genetic-interaction
maps, termed E-MAPs (epistatic miniarray profiles), comprising quantitative measures of …

Combinatorial libraries of synthetic and natural products are an important source of
molecular information for the interrogation of biological targets. Methods for the intracellular …

Cell-cycle dysregulation is a hallmark of tumor cells. The ability of normal cells to undergo
cell-cycle arrest after damage to DNA is crucial for the maintenance of genomic integrity. The …

Chemical genetics is the study of gene-product function in a cellular or organismal context
using exogenous ligands. In this approach, small molecules that bind directly to proteins are …

The use of so‐called protein scaffolds has recently attracted considerable attention in
biochemistry in the context of generating novel types of ligand receptors for various …

▪ Abstract Golgi inheritance proceeds via sequential biogenesis and partitioning phases.
Although little is known about Golgi growth and replication (biogenesis), ultrastructural and …

The mammalian Golgi apparatus exists as stacks of cisternae that are laterally linked to form
a continuous membrane ribbon, but neither the molecular requirements for, nor the purpose …

Saccharomyces cerevisiae responds to mating pheromones by activating a receptor–G-
protein-coupled mitogen-activated protein kinase (MAPK) cascade that is also used by other …