Oxazole compounds containing nitrogen and oxygen atoms in the five-membered aromatic
ring are readily able to bind with a variety of enzymes and receptors in biological systems …

The polarization of tumor-associated macrophages (TAMs) from M2 to M1 phenotype
demonstrates great potential for remodeling the immunosuppressive tumor …

Pattern recognition receptors (PRRs) represent a re-emerging class of therapeutic targets for
vaccine adjuvants, inflammatory diseases and cancer. In this review article, we summarize …

Toll-like receptors (TLRs) are members of a large family of evolutionarily conserved pattern
recognition receptors (PRRs), which serve as key components of the innate immune system …

Several toll-like receptors (TLRs) reside inside endosomes of specific immune cells—among
them, aberrant activation of TLR7 and TLR9 is implicated in myriad contexts of autoimmune …

Undesirable activation of endosomal toll-like receptors TLR7 and TLR9 present in specific
immune cells in response to host-derived ligands is implicated in several autoimmune …

Toll-like receptor 7 (TLR7) is activated in response to the binding of single-stranded RNA. Its
over-activation has been implicated in several autoimmune disorders, and thus, it is an …

TLR9 is one of the major innate immune receptors expressed in the endosomes of pDCs
and B cells in humans. Aberrant TLR9 activation is implicated in several autoimmune and …

Aberrant activation of the endosomal Toll-like receptor 7 (TLR7) has been implicated in
myriad autoimmune diseases and is an established therapeutic target in such conditions …

Abstract hERG is considered to be a primary anti‐target in the drug development process, as
the K+ channel encoded by hERG plays an important role in cardiac re‐polarization. It is …