The endoplasmic reticulum (ER) is a dynamic intracellular organelle with multiple functions
essential for cellular homeostasis, development, and stress responsiveness. In response to …

Protein structures are essential to understanding cellular processes in molecular detail.
While advances in artificial intelligence revealed the tertiary structure of proteins at scale …

In eukaryotic cells terminally misfolded proteins of the secretory pathway are retarded in the
endoplasmic reticulum (ER) and subsequently degraded in a ubiquitin‐proteasome …

Selenoprotein K (SelK) is an 11-kDa endoplasmic reticulum (ER) protein of unknown
function. Herein, we defined a new eukaryotic protein family that includes SelK …

Nearly one-third of proteins are initially targeted to the endoplasmic reticulum (ER)
membrane, where they are correctly folded and then delivered to their final cellular …

Background & aims Unrestricted endoplasmic reticulum (ER) stress and the continuous
activation of ER associated protein degradation (ERAD) pathway might lead to the …

Abstract Background Aberrant Derlin-1 (DERL1) expression is associated with an
overactivation of p-AKT, whose involvement in breast cancer (BRCA) development has been …

Disruption of the gene BSCL2 causes a severe, generalised lipodystrophy, demonstrating
the critical role of its protein product, seipin, in human adipose tissue development. Seipin is …

Endoplasmic reticulum (ER)-associated protein degradation (ERAD) is a quality control
system that induces the degradation of ER terminally misfolded proteins. The ERAD system …

The membrane integration of polytopic proteins is coordinated at the endoplasmic reticulum
(ER) by the conserved Sec61 translocon, which facilitates the lateral release of …