The cause of insulin resistance in obesity and type 2 diabetes mellitus (T2DM) is not limited
to impaired insulin signalling but also involves the complex interplay of multiple metabolic …

The breakthrough discoveries of leptin and adiponectin more than two decades ago led to a
widespread recognition of adipose tissue as an endocrine organ. Many more adipose tissue …

ABSTRACT Molnupiravir (EIDD-2801/MK-4482), the prodrug of the active antiviral
ribonucleoside analog β-d-N4-hydroxycytidine (NHC; EIDD-1931), has activity against a …

Eight G protein‐coupled P2Y receptor subtypes respond to extracellular adenine and uracil
mononucleotides and dinucleotides. P2Y receptors belong to the δ group of rhodopsin‐like …

The initial discovery that ob/ob mice become obese because of a recessive mutation of the
leptin gene has been crucial to discover the melanocortin pathway to control appetite. In the …

Liver mitochondria undergo architectural remodeling that maintains energy homeostasis in
response to feeding and fasting. However, the specific components and molecular …

Obesity is the most common nutritional disorder worldwide and is associated with
dyslipidemia and atherosclerotic cardiovascular disease. The hallmark of dyslipidemia in …

Background Maternal obesity is a risk factor for childhood obesity; this is a major public
health concern given that∼ 40% of pregnant women are either overweight or obese …

Excess adiposity can induce adverse sequelae in multiple cell types and organ systems.
The transition from the lean to the obese state is characterized by fundamental cellular …

Small cell lung cancer (SCLC) is an aggressive lung cancer subtype with extremely poor
prognosis. No targetable genetic driver events have been identified, and the treatment …