Emerging targets in cancer immunotherapy
S Burugu, AR Dancsok, TO Nielsen - Seminars in cancer biology, 2018 - Elsevier
The first generation of immune checkpoint inhibitors (anti-CTLA-4 and anti-PD-1/PD-L1)
targeted natural immune homeostasis pathways, co-opted by cancers, to drive anti-tumor …
targeted natural immune homeostasis pathways, co-opted by cancers, to drive anti-tumor …
CAR-engineered NK cells for the treatment of glioblastoma: turning innate effectors into precision tools for cancer immunotherapy
Glioblastoma (GB) is the most common and aggressive primary brain tumor in adults and
currently incurable. Despite multimodal treatment regimens, median survival in unselected …
currently incurable. Despite multimodal treatment regimens, median survival in unselected …
Innate receptors with high specificity for HLA class I–peptide complexes
Genetic studies associate killer cell immunoglobulin-like receptors (KIRs) and their HLA
class I ligands with a variety of human diseases. The basis for these associations and the …
class I ligands with a variety of human diseases. The basis for these associations and the …
Friends with benefits: chemokines, glioblastoma-associated microglia/macrophages, and tumor microenvironment
E Codrici, ID Popescu, C Tanase, AM Enciu - International journal of …, 2022 - mdpi.com
Glioma is the most common primary intracranial tumor and has the greatest prevalence of all
brain tumors. Treatment resistance and tumor recurrence in GBM are mostly explained by …
brain tumors. Treatment resistance and tumor recurrence in GBM are mostly explained by …
Human NK cell receptor KIR2DS4 detects a conserved bacterial epitope presented by HLA-C
Natural killer (NK) cells have an important role in immune defense against viruses and
cancer. Activation of human NK cell cytotoxicity toward infected or tumor cells is regulated by …
cancer. Activation of human NK cell cytotoxicity toward infected or tumor cells is regulated by …
The role of NK cells and innate lymphoid cells in brain cancer
The brain is considered an immune privileged site due to the high selectivity of the blood-
brain barrier which restricts the passage of molecules and cells into the brain parenchyma …
brain barrier which restricts the passage of molecules and cells into the brain parenchyma …
A transcriptional signature of PDGF-DD activated natural killer cells predicts more favorable prognosis in low-grade glioma
The binding of platelet-derived growth factor D (PDGF-DD) to the NKp44 receptor activates a
distinct transcriptional program in primary IL-2 expanded human natural killer (NK) cells. We …
distinct transcriptional program in primary IL-2 expanded human natural killer (NK) cells. We …
Immune surveillance in glioblastoma: Role of the NKG2D system and novel cell‐based therapeutic approaches
G Chitadze, D Kabelitz - Scandinavian Journal of Immunology, 2022 - Wiley Online Library
Glioblastoma, formerly known as glioblastoma multiforme (GBM), is the most frequent and
most aggressive brain tumour in adults. The brain is an immunopriviledged organ, and the …
most aggressive brain tumour in adults. The brain is an immunopriviledged organ, and the …
Presence of the human cytomegalovirus in glioblastomas—A systematic review
I Peredo-Harvey, A Rahbar, C Söderberg-Nauclér - Cancers, 2021 - mdpi.com
Simple Summary Whether the human cytomegalovirus (HCMV) is present in samples
obtained from patients with glioblastoma (GBM) has been a matter under debate during the …
obtained from patients with glioblastoma (GBM) has been a matter under debate during the …
Potential role of Hsp70 and activated NK cells for prediction of prognosis in glioblastoma patients
Despite rapid progress in the treatment of many cancers, glioblastoma remains a
devastating disease with dismal prognosis. The aim of this study was to identify chaperone …
devastating disease with dismal prognosis. The aim of this study was to identify chaperone …