Biomaterials: foreign bodies or tuners for the immune response?

E Mariani, G Lisignoli, RM Borzì… - International journal of …, 2019‏ - mdpi.com
The perspectives of regenerative medicine are still severely hampered by the host response
to biomaterial implantation, despite the robustness of technologies that hold the promise to …

The pathology of the foreign body reaction against biomaterials

R Klopfleisch, F Jung - … of biomedical materials research Part A, 2017‏ - Wiley Online Library
The healing process after implantation of biomaterials involves the interaction of many
contributing factors. Besides their in vivo functionality, biomaterials also require …

Osteoimmunomodulation for the development of advanced bone biomaterials

Z Chen, T Klein, RZ Murray, R Crawford, J Chang… - Materials today, 2016‏ - Elsevier
As direct effector cells for osteogenesis, osteoblastic cells are commonly used for evaluating
the in vitro osteogenic capacity of bone biomaterials, and the traditional biological principle …

Macrophages, foreign body giant cells and their response to implantable biomaterials

Z Sheikh, PJ Brooks, O Barzilay, N Fine, M Glogauer - Materials, 2015‏ - mdpi.com
All biomaterials, when implanted in vivo, elicit cellular and tissue responses. These
responses include the inflammatory and wound healing responses, foreign body reactions …

Immune responses to implants–a review of the implications for the design of immunomodulatory biomaterials

S Franz, S Rammelt, D Scharnweber, JC Simon - Biomaterials, 2011‏ - Elsevier
A key for long-term survival and function of biomaterials is that they do not elicit a detrimental
immune response. As biomaterials can have profound impacts on the host immune …

Modulation of immune-inflammatory responses through surface modifications of biomaterials to promote bone healing and regeneration

F Batool, H Özçelik, C Stutz… - Journal of Tissue …, 2021‏ - journals.sagepub.com
Control of inflammation is indispensable for optimal oral wound healing and tissue
regeneration. Several biomaterials have been used to enhance the regenerative outcomes; …

OsteoMacs: Key players around bone biomaterials

RJ Miron, DD Bosshardt - Biomaterials, 2016‏ - Elsevier
Osteal macrophages (OsteoMacs) are a special subtype of macrophage residing in bony
tissues. Interesting findings from basic research have pointed to their vast and substantial …

Foreign body reaction to biomaterials

JM Anderson, A Rodriguez, DT Chang - Seminars in immunology, 2008‏ - Elsevier
The foreign body reaction composed of macrophages and foreign body giant cells is the end-
stage response of the inflammatory and wound healing responses following implantation of …

Characterization of topographical effects on macrophage behavior in a foreign body response model

S Chen, JA Jones, Y Xu, HY Low, JM Anderson… - Biomaterials, 2010‏ - Elsevier
Current strategies to limit macrophage adhesion, fusion and fibrous capsule formation in the
foreign body response have focused on modulating material surface properties. We …

The foreign body response: at the interface of surgery and bioengineering

MR Major, VW Wong, ER Nelson… - Plastic and …, 2015‏ - journals.lww.com
Background: The surgical implantation of materials and devices has dramatically increased
over the past decade. This trend is expected to continue with the broadening application of …