Biology and relevance of human acute myeloid leukemia stem cells
D Thomas, R Majeti - Blood, The Journal of the American …, 2017 - ashpublications.org
Evidence of human acute myeloid leukemia stem cells (AML LSCs) was first reported nearly
2 decades ago through the identification of rare subpopulations of engrafting cells in …
2 decades ago through the identification of rare subpopulations of engrafting cells in …
Cancer transcriptome profiling at the juncture of clinical translation
Methodological breakthroughs over the past four decades have repeatedly revolutionized
transcriptome profiling. Using RNA sequencing (RNA-seq), it has now become possible to …
transcriptome profiling. Using RNA sequencing (RNA-seq), it has now become possible to …
Pseudouridine-modified tRNA fragments repress aberrant protein synthesis and predict leukaemic progression in myelodysplastic syndrome
Transfer RNA-derived fragments (tRFs) are emerging small noncoding RNAs that, although
commonly altered in cancer, have poorly defined roles in tumorigenesis. Here we show that …
commonly altered in cancer, have poorly defined roles in tumorigenesis. Here we show that …
Stem cell gene expression programs influence clinical outcome in human leukemia
Xenograft studies indicate that some solid tumors and leukemias are organized as cellular
hierarchies sustained by cancer stem cells (CSCs). Despite the promise of the CSC model …
hierarchies sustained by cancer stem cells (CSCs). Despite the promise of the CSC model …
Clonal evolution of preleukemic hematopoietic stem cells precedes human acute myeloid leukemia
Given that most bone marrow cells are short-lived, the accumulation of multiple
leukemogenic mutations in a single clonal lineage has been difficult to explain. We propose …
leukemogenic mutations in a single clonal lineage has been difficult to explain. We propose …
The serotonin transporter promoter variant (5-HTTLPR), stress, and depression meta-analysis revisited: evidence of genetic moderation
Objective: To perform a meta-analysis including all relevant studies exploring the interaction.
Data Sources: We identified studies published through November 2009 in PubMed. Study …
Data Sources: We identified studies published through November 2009 in PubMed. Study …
[HTML][HTML] CD47 is an adverse prognostic factor and therapeutic antibody target on human acute myeloid leukemia stem cells
Acute myeloid leukemia (AML) is organized as a cellular hierarchy initiated and maintained
by a subset of self-renewing leukemia stem cells (LSC). We hypothesized that increased …
by a subset of self-renewing leukemia stem cells (LSC). We hypothesized that increased …
Hematopoietic stem cell: self‐renewal versus differentiation
The mammalian blood system, containing more than 10 distinct mature cell types, stands on
one specific cell type, hematopoietic stem cell (HSC). Within the system, only HSCs possess …
one specific cell type, hematopoietic stem cell (HSC). Within the system, only HSCs possess …
Targeting cancer stem cells by inhibiting Wnt, Notch, and Hedgehog pathways
N Takebe, PJ Harris, RQ Warren, SP Ivy - Nature reviews Clinical …, 2011 - nature.com
Tumor relapse and metastasis remain major obstacles for improving overall cancer survival,
which may be due at least in part to the existence of cancer stem cells (CSCs). CSCs are …
which may be due at least in part to the existence of cancer stem cells (CSCs). CSCs are …
Differences and similarities between cancer and somatic stem cells: therapeutic implications
F Rossi, H Noren, R Jove, V Beljanski… - Stem cell research & …, 2020 - Springer
Over the last decades, the cancer survival rate has increased due to personalized therapies,
the discovery of targeted therapeutics and novel biological agents, and the application of …
the discovery of targeted therapeutics and novel biological agents, and the application of …