There has been a significant progress in our understanding of the molecular mechanisms by
which calcium (Ca2+) ions mediate various types of cardiac arrhythmias. A growing list of …

Troponin complex is a component of skeletal and cardiac muscle thin filaments. It consists of
three subunits—troponin I, T, and C, and it plays a crucial role in muscle activity, connecting …

Background: Childhood cardiomyopathies are progressive and often lethal disorders,
forming the most common cause of heart failure in children. Despite severe outcomes, their …

The sarcomeric proteins represent the structural building blocks of heart muscle, which are
essential for contraction and relaxation. During recent years, it has become evident that …

In striated muscle, the protein troponin complex turns contraction on and off in a calcium-
dependent manner. The calcium-sensing component of the complex is troponin C, which is …

All muscle contraction occurs due to the cyclical interaction between sarcomeric thin and
thick filament proteins within the myocyte. The thin filament consists of the proteins actin …

Heart failure (HF) presents a significant clinical challenge, with current treatments mainly
easing symptoms without stop** disease progression. The targeting of calcium (Ca2+) …

Life-threatening ventricular arrhythmias are the main clinical burden in patients with
hypertrophic cardiomyopathy (HCM), and frequently occur in young patients with mild …

Background The troponin complex plays a crucial role in regulating skeletal and cardiac
contraction. Congenital myopathies can occur due to several mutations in genes that …

Introduction Troponin (TNN)-encoded cardiac troponins (Tn) are critical for sensing calcium
and triggering myofilament contraction. TNN variants are associated with development of …