In eukaryotic genomes, transcriptional machinery and nucleosomes compete for binding to
DNA sequences; thus, a crucial aspect of gene regulatory element function is to modulate …

Every cell must solve the problem of how to fold its genome. We describe how the folded
state of chromosomes is the result of the combined activity of multiple conserved …

Although enhancers are central regulators of mammalian gene expression, the mechanisms
underlying enhancer–promoter (EP) interactions remain unclear. Chromosome …

DNA supercoiling is a biophysical feature of the double helix with a pivotal role in biological
processes. However, understanding of DNA supercoiling in the chromatin remains limited …

During each cell cycle, the process of DNA replication timing is tightly regulated to ensure
the accurate duplication of the genome. The extent and significance of alterations in this …

Contacts between enhancers and promoters are thought to relate to their ability to activate
transcription. Investigating factors that contribute to such chromatin interactions is therefore …

The chromosomes in multicellular eukaryotes are organized into a series of topologically
independent loops called TADs. In flies, TADs are formed by physical interactions between …

Highlights•Microenvironments are local high concentrations of multiple nuclear factors.•
Microenvironments form due to protein–protein and protein–chromatin interactions.•Local …

SJ Gould and R. Lewontin in their famous “Spandrels paper”(1979) argued that many
anatomical elements arise in evolution not due to their “current utility” but rather due to other …

Secondary trastuzumab resistance represents an evolutionary adaptation of HER2‐positive
breast cancer during anti‐HER2 treatment. Most current studies have tended to prioritize …