Mesh nebulizers have become the first choice for new nebulized pharmaceutical drug developments

JN Pritchard, RHM Hatley, J Denyer… - Therapeutic Delivery, 2018‏ - Taylor & Francis
In the 24 years since first being marketed, the mesh nebulizer has been developed by five
main manufacturers into a viable solution for the delivery of high-value nebulized drugs …

High-flow nasal cannula oxygen therapy: physiological mechanisms and clinical applications in children

S Nolasco, S Manti, S Leonardi, C Vancheri… - Frontiers in …, 2022‏ - frontiersin.org
High-flow nasal cannula (HFNC) oxygen therapy has rapidly become a popular modality of
respiratory support in pediatric care. This is undoubtedly due to its ease of use and safety …

Aerosol drug delivery to spontaneously-breathing preterm neonates: lessons learned

F Bianco, F Salomone, I Milesi, X Murgia, S Bonelli… - Respiratory …, 2021‏ - Springer
Delivery of medications to preterm neonates receiving non-invasive ventilation (NIV)
represents one of the most challenging scenarios for aerosol medicine. This challenge is …

In vitro–in vivo correlation of intranasal drug deposition

S Le Guellec, S Ehrmann, L Vecellio - Advanced Drug Delivery Reviews, 2021‏ - Elsevier
In vitro–in vivo correlation (IVIVC) allows prediction of in vivo drug deposition from a nasally
inhaled drug based on in vitro drug measurements. In vitro measurements include physical …

Nasal high flow in management of children with status asthmaticus: a retrospective observational study

F Baudin, A Buisson, B Vanel, B Massenavette… - Annals of Intensive …, 2017‏ - Springer
Background Asthma is the most common obstructive airway disease in children and adults.
Nasal high flow (NHF) is a recent device that is now used as a primary support for …

Not all nebulizers are created equal: Considerations in choosing a nebulizer for aerosol delivery during mechanical ventilation

R MacLoughlin, I Martin-Loeches - Expert Review of Respiratory …, 2023‏ - Taylor & Francis
Introduction Aerosol therapy is commonly prescribed in the mechanically ventilated patient.
Jet nebulizers (JN) and vibrating mesh nebulizers (VMN) are the most common nebulizer …

A narrative review on trans-nasal pulmonary aerosol delivery

J Li, JB Fink, R MacLoughlin, R Dhand - Critical Care, 2020‏ - Springer
The use of trans-nasal pulmonary aerosol delivery via high-flow nasal cannula (HFNC) has
expanded in recent years. However, various factors influencing aerosol delivery in this …

Decrease the flow setting to improve trans‐nasal pulmonary aerosol delivery via “high‐flow nasal cannula” to infants and toddlers

J Li, L Gong, A Ari, JB Fink - Pediatric pulmonology, 2019‏ - Wiley Online Library
Objectives Trans‐nasal pulmonary aerosol delivery for infants and toddlers has recently
gained popularity, however, the reported lung deposition is low. We aimed to investigate the …

The influence of changing interfaces on aerosol delivery within high flow oxygen setting in adults: an in-vitro study

YM Madney, NI Laz, AA Elberry, H Rabea… - Journal of Drug Delivery …, 2020‏ - Elsevier
Despite the fact that the nasal-cannula is more comfortable than facemask, using facemask
with high flow oxygen therapy (HFOT) may be beneficial in mouth-breathers. The aim of the …

Nasal high-flow bronchodilator nebulization: a randomized cross-over study

F Reminiac, L Vecellio, L Bodet-Contentin… - Annals of intensive …, 2018‏ - Springer
Background There is an absence of controlled clinical data showing bronchodilation
effectiveness after nebulization via nasal high-flow therapy circuits. Results Twenty-five …