Glioblastoma (GBM), the predominant and primary malignant intracranial tumor, poses a
formidable challenge due to its immunosuppressive microenvironment, thereby confounding …

MicroRNAs (miRNAs) are mighty post-transcriptional regulators in cell physiology and
pathophysiology. In this review, we focus on the role of miR-223-3p (henceforth miR-223) in …

The KRAS G12D mutation is very frequent in many cancers, such as pancreatic, colon and
lung, and has remained undruggable for the past three decades, due to its smooth surface …

A series of new compounds based on 8-methyl-2-phenyl quinazolinone Schiff's base were
synthesized from 3-amino quinazolinone intermediates. These compounds were evaluated …

Glioblastoma multiforme (GBM) is a heterogeneous, aggressive brain cancer characterized
by chemo-resistance and cancer stemness. Histone deacetylases (HDACs) are a group of …

Abstract Ten hexahydropyrimido [4, 5-d] pyrimidine derivatives have been synthesized by
using a green and time-efficient microwave method. The synthesized motifs were evaluated …

Melanin is a natural pigment present in plants, animals, humans, and pigment-producing
bacteria. Due to their biocompatibility and versatile biological activities, it was heavily used …

Colorectal cancer (CRC) has become a global threat worldwide with constantly increasing
incidence and mortality rates every year, especially in the US and China. Janus kinase …

Ten new non-nucleophilic base (DBU) catalyzed oxazolone-bearing pyrazole derivatives
were created to treat infectious diseases caused by bacterial, mycobacterial strains, and …

Copper (Cu) is an important coenzyme factor in cell signaling, such as cytochrome c oxidase
(Complex IV). Metabolism plays an important role in regulating the fate of mammalian cells …