The hallmarks of cancer conceptualization is a heuristic tool for distilling the vast complexity
of cancer phenotypes and genotypes into a provisional set of underlying principles. As …

Epigenetic aberrations, which are recognized as key drivers of several human diseases, are
often caused by genetic defects that result in functional deregulation of epigenetic proteins …

Gene expression by RNA polymerase II (RNAPII) is tightly controlled by cyclin-dependent
kinases (CDKs) at discrete checkpoints during the transcription cycle. The pausing …

The concept of differentiation therapy emerged from the fact that hormones or cytokines may
promote differentiation ex vivo, thereby irreversibly changing the phenotype of cancer cells …

The bromodomain (BRD) and extraterminal (BET) proteins including BRD2, BRD3 and
BRD4 have been identified as key targets for leukemia maintenance. A novel oral inhibitor of …

Histones are the main structural proteins of eukaryotic chromatin. Histone acetylation/
deacetylation are the epigenetic mechanisms of the regulation of gene expression and are …

Hierarchical organization of tissues relies on stem cells, which either self-renew or produce
committed progenitors predestined for lineage differentiation. Here we identify HOXA5 as an …

Acute myeloid leukemia (AML) with t (8; 21)(q22; q22. 1); RUNX1-RUNX1T1, one of the core-
binding factor leukemias, is one of the most common subtypes of AML with recurrent genetic …

Acute myeloid leukemia (AML) is a heterogeneous hematologic malignancy in terms of
clinical features, underlying pathogenesis and treatment outcomes. Recent advances in …

Acute myeloid leukemia is characterized by arrested differentiation, and agents that
overcome this block are therapeutically useful, as shown by the efficacy of all-trans retinoic …