Introduction: Molecular dynamics (MD) simulations can provide not only plentiful dynamical
structural information on biomacromolecules but also a wealth of energetic information …

Creutzfeldt–Jakob disease (CJD) is a rapidly progressive, fatal and transmissible
neurodegenerative disease associated with the accumulation of misfolded prion protein in …

Neurodegenerative diseases are characterised by the irreversible degeneration of neurons
in the central or peripheral nervous systems. These include amyotrophic lateral sclerosis …

Although the diagnosis of dementia still is primarily based on clinical criteria, neuroimaging
is playing an increasingly important role. This is in large part due to advances in techniques …

Genetic prion diseases (gPrDs) caused by mutations in the prion protein gene (PRNP) have
been classified as genetic Creutzfeldt–Jakob disease, Gerstmann–Sträussler–Scheinker …

Objective To determine whether preventive trials in genetic prion disease could be designed
to follow presymptomatic mutation carriers to onset of disease. Methods We assembled age …

Prion disease is a rare, fatal, and often rapidly progressive neurodegenerative disease. Ten
to fifteen percent of cases are caused by autosomal dominant gain-of-function variants in the …

Genetic prion diseases are a rare and diverse group of fatal neurodegenerative disorders
caused by pathogenic sequence variations in the prion protein gene, PRNP. Data on CSF …

Fatal familial insomnia (FFI) and sporadic fatal insomnia (sFI), or thalamic form of sporadic
Creutzfeldt–Jakob disease MM2 (sCJDMM2T), are prion diseases originally named and …

Background Prion disease is neurodegenerative disease that is typically fatal within months
of first symptoms. Clinical trials in this rapidly declining symptomatic patient population have …