Profiling cell identity and tissue architecture with single-cell and spatial transcriptomics
Single-cell transcriptomics has broadened our understanding of cellular diversity and gene
expression dynamics in healthy and diseased tissues. Recently, spatial transcriptomics has …
expression dynamics in healthy and diseased tissues. Recently, spatial transcriptomics has …
Map** the genomic diaspora of gastric cancer
Gastric cancer (GC) is a leading contributor to global cancer incidence and mortality.
Pioneering genomic studies, focusing largely on primary GCs, revealed driver alterations in …
Pioneering genomic studies, focusing largely on primary GCs, revealed driver alterations in …
γδ T cells are effectors of immunotherapy in cancers with HLA class I defects
DNA mismatch repair-deficient (MMR-d) cancers present an abundance of neoantigens that
is thought to explain their exceptional responsiveness to immune checkpoint blockade …
is thought to explain their exceptional responsiveness to immune checkpoint blockade …
Mismatch repair deficiency is not sufficient to elicit tumor immunogenicity
DNA mismatch repair deficiency (MMRd) is associated with a high tumor mutational burden
(TMB) and sensitivity to immune checkpoint blockade (ICB) therapy. Nevertheless, most …
(TMB) and sensitivity to immune checkpoint blockade (ICB) therapy. Nevertheless, most …
Neoadjuvant nivolumab plus ipilimumab and adjuvant nivolumab in localized deficient mismatch repair/microsatellite instability–high gastric or esophagogastric …
PURPOSE In patients with resectable gastric/gastroesophageal junction (GEJ)
adenocarcinoma, surgery plus perioperative platinum-based chemotherapy is the standard …
adenocarcinoma, surgery plus perioperative platinum-based chemotherapy is the standard …
Advances in single-cell RNA sequencing and its applications in cancer research
D Huang, N Ma, X Li, Y Gou, Y Duan, B Liu… - Journal of hematology & …, 2023 - Springer
Cancers are a group of heterogeneous diseases characterized by the acquisition of
functional capabilities during the transition from a normal to a neoplastic state. Powerful …
functional capabilities during the transition from a normal to a neoplastic state. Powerful …
The new era of immunotherapy in gastric cancer
S Takei, A Kawazoe, K Shitara - Cancers, 2022 - mdpi.com
Simple Summary Advanced gastric cancer remains a malignancy with a poor prognosis,
with a median survival of about 12–15 months. In recent years, immune checkpoint inhibitors …
with a median survival of about 12–15 months. In recent years, immune checkpoint inhibitors …
[HTML][HTML] Phase II, single-arm trial of preoperative short-course radiotherapy followed by chemotherapy and camrelizumab in locally advanced rectal cancer
Z Lin, M Cai, P Zhang, G Li, T Liu, X Li… - … for immunotherapy of …, 2021 - ncbi.nlm.nih.gov
Background In locally advanced rectal cancer (LARC), preoperative short-course
radiotherapy (SCRT) with delayed surgery has been shown to be as effective as long-course …
radiotherapy (SCRT) with delayed surgery has been shown to be as effective as long-course …
Early tumor–immune microenvironmental remodeling and response to first-line fluoropyrimidine and platinum chemotherapy in advanced gastric cancer
Chemotherapy is ubiquitous in first-line treatment of advanced gastric cancer, yet responses
are heterogeneous, and little is known about mediators of chemotherapy response. To move …
are heterogeneous, and little is known about mediators of chemotherapy response. To move …
Tumour mutational burden: clinical utility, challenges and emerging improvements
Tumour mutational burden (TMB), defined as the total number of somatic non-synonymous
mutations present within the cancer genome, varies across and within cancer types. A first …
mutations present within the cancer genome, varies across and within cancer types. A first …