Influenza A viruses (IAVs) possess a great zoonotic potential as they are able to infect
different avian and mammalian animal hosts, from which they can be transmitted to humans …

Influenza virus is a major human pathogen that causes annual epidemics and occasional
pandemics. Moreover, the virus causes outbreaks in poultry and other animals, such as pigs …

To establish a new lineage in the human population, avian influenza A viruses (AIV) must
overcome the intracellular restriction factor MxA. Partial escape from MxA restriction can be …

The influenza A virus RNA genome segments are packaged in ribonucleoprotein complexes
containing RNA polymerase and nucleoprotein. The ribonucleoprotein is involved in the …

Avian influenza A viruses, such as the highly pathogenic avian H5N1 viruses, sporadically
enter the human population but often do not transmit between individuals. In rare cases …

The interferon-induced dynamin-like MxA GTPase restricts the replication of influenza A
viruses. We identified adaptive mutations in the nucleoprotein (NP) of pandemic strains …

Background Influenza is a common infectious disease caused by influenza viruses. Annual
epidemics cause severe illnesses, deaths, and economic loss around the world. To better …

As a major component of the viral ribonucleoprotein (vRNP) complex in influenza A virus
(IAV), nucleoprotein (NP) interacts with isoforms of importin α family members, leading to the …

Protein phosphorylation is a common post-translational modification in eukaryotic cells and
has a wide range of functional effects. Here, we used mass spectrometry to search for …

Uncoating is an obligatory step in the virus life cycle that serves as an antiviral target.
Unfortunately, it is challenging to study viral uncoating due to methodology limitations for …