Many protein-coding genes in higher eukaryotes can produce circular RNAs (circRNAs)
through back-splicing of exons. CircRNAs differ from mRNAs in their production, structure …

High-throughput sequencing-based methods and their applications in the study of
transcriptomes have revolutionized our understanding of alternative splicing. Networks of …

Covalently closed circular RNAs (circRNAs) are produced by precursor mRNA back-splicing
of exons of thousands of genes in eukaryotes. circRNAs are generally expressed at low …

The synthesis of pre-mRNA by RNA polymerase II (Pol II) involves the formation of a
transcription initiation complex, and a transition to an elongation complex,,–. The large …

Abstract N 6-methyladenosine (m6A) is a chemical modification present in multiple RNA
species, being most abundant in mRNAs. Studies on enzymes or factors that catalyze …

Circular RNAs (circRNAs) are closed long non-coding RNAs, in which the 5'and 3'termini
are covalently linked by back-splicing of exons from a single pre-mRNA. Emerging evidence …

Many eukaryotic protein-coding genes are able to generate exonic circular RNAs. Most of
these covalently linked transcripts are expressed at low levels, but some accumulate to …

The first circular RNA (circRNA) was identified more than 40 years ago, but it was only
recently appreciated that circRNAs are common outputs of many eukaryotic protein‐coding …

Steady-state circular RNAs (circRNAs) have been mapped to thousands of genomic loci in
mammals. We studied circRNA processing using metabolic tagging of nascent RNAs with 4 …

Abstract The role of Fat Mass and Obesity-associated protein (FTO) and its substrate N6-
methyladenosine (m 6 A) in mRNA processing and adipogenesis remains largely unknown …