Deciphering breast cancer: from biology to the clinic
Breast cancer remains a leading cause of cancer-related mortality in women, reflecting
profound disease heterogeneity, metastasis, and therapeutic resistance. Over the last …
profound disease heterogeneity, metastasis, and therapeutic resistance. Over the last …
Pathogenesis of triple-negative breast cancer
Triple-negative breast cancer (TNBC) encompasses a heterogeneous group of
fundamentally different diseases with different histologic, genomic, and immunologic …
fundamentally different diseases with different histologic, genomic, and immunologic …
A single-cell and spatially resolved atlas of human breast cancers
Breast cancers are complex cellular ecosystems where heterotypic interactions play central
roles in disease progression and response to therapy. However, our knowledge of their …
roles in disease progression and response to therapy. However, our knowledge of their …
Tumor initiation and early tumorigenesis: molecular mechanisms and interventional targets
S Zhang, X **ao, Y Yi, X Wang, L Zhu, Y Shen… - Signal transduction and …, 2024 - nature.com
Tumorigenesis is a multistep process, with oncogenic mutations in a normal cell conferring
clonal advantage as the initial event. However, despite pervasive somatic mutations and …
clonal advantage as the initial event. However, despite pervasive somatic mutations and …
Towards targeting the breast cancer immune microenvironment
The tumour immune microenvironment is shaped by the crosstalk between cancer cells,
immune cells, fibroblasts, endothelial cells and other stromal components. Although the …
immune cells, fibroblasts, endothelial cells and other stromal components. Although the …
[HTML][HTML] Distinct contributions of partial and full EMT to breast cancer malignancy
Epithelial-mesenchymal transition (EMT) is a transient, reversible process of cell de-
differentiation where cancer cells transit between various stages of an EMT continuum …
differentiation where cancer cells transit between various stages of an EMT continuum …
A single‐cell RNA expression atlas of normal, preneoplastic and tumorigenic states in the human breast
To examine global changes in breast heterogeneity across different states, we determined
the single‐cell transcriptomes of> 340,000 cells encompassing normal breast, preneoplastic …
the single‐cell transcriptomes of> 340,000 cells encompassing normal breast, preneoplastic …
Wnt signaling in breast cancer: biological mechanisms, challenges and opportunities
X Xu, M Zhang, F Xu, S Jiang - Molecular cancer, 2020 - Springer
Wnt signaling is a highly conserved signaling pathway that plays a critical role in controlling
embryonic and organ development, as well as cancer progression. Genome-wide …
embryonic and organ development, as well as cancer progression. Genome-wide …
Single-cell transcriptional diversity is a hallmark of developmental potential
Single-cell RNA sequencing (scRNA-seq) is a powerful approach for reconstructing cellular
differentiation trajectories. However, inferring both the state and direction of differentiation is …
differentiation trajectories. However, inferring both the state and direction of differentiation is …
Multi-omics analysis identifies therapeutic vulnerabilities in triple-negative breast cancer subtypes
Triple-negative breast cancer (TNBC) is a collection of biologically diverse cancers
characterized by distinct transcriptional patterns, biology, and immune composition. TNBCs …
characterized by distinct transcriptional patterns, biology, and immune composition. TNBCs …