Cellular actin networks exhibit a wide range of sizes, shapes, and architectures tailored to
their biological roles. Once assembled, these filamentous networks are either maintained in …

The actin depolymerizing factor (ADF)/cofilin family comprises small actin-binding proteins
with crucial roles in development, tissue homeostasis and disease. They are best known for …

The Arp2/3 complex is an evolutionary conserved molecular machine that generates
branched actin networks. When activated, the Arp2/3 complex contributes the actin …

Lamellipodia and ruffles are veil-shaped cell protrusions composed of a highly branched
actin filament meshwork assembled by the Arp2/3 complex. These structures not only …

Various cellular processes (including cell motility) are driven by the regulated, polarized
assembly of actin filaments into distinct force-producing arrays of defined size and …

Coordinated polymerization of actin filaments provides force for cell migration,
morphogenesis and endocytosis. Cap** protein (CP) is a central regulator of actin …

Identification of actin-depolymerizing factor homology (ADF-H) domains in the structures of
several related proteins led first to the formation of the ADF/cofilin family, which then …

Cell migration is necessary for several developmental processes in multicellular organisms.
Furthermore, many physiological processes such as wound healing and immunological …

Haptotaxis is the process by which cells respond to gradients of substrate-bound cues, such
as extracellular matrix proteins (ECM); however, the cellular mechanism of this response …

Migrating cells move across diverse assemblies of extracellular matrix (ECM) that can be
separated by micron-scale gaps. For membranes to protrude and reattach across a gap …