Biophysical and structural investigations are presented with a focus on the membrane lipid
interactions of cationic linear antibiotic peptides such as magainin, PGLa, LL37, and melittin …

Even 30 years after the discovery of magainins, biophysical and structural investigations on
how these peptides interact with membranes can still bear surprises and add new …

The global increase in antimicrobial drug resistance has dramatically reduced the
effectiveness of traditional antibiotics. Structurally diverse antibiotics are urgently needed to …

We describe the design of peptides with properties like thermostability, pH stability, and
antibacterial activity against a few bacterial food pathogens. Insights obtained from classical …

We review the use of molecular dynamics (MD) simulation as a drug design tool in the
context of the role that the lipid membrane can play in drug action, ie, the interaction …

The study of peptide-lipid and peptide-peptide interactions as well as their topology and
dynamics using biophysical and structural approaches have changed our view how …

Every cell is protected by a semipermeable membrane. Peptides with the right properties, for
example Antimicrobial peptides (AMPs), can disrupt this protective barrier by formation of …

Scorpion venom constitutes a rich source of biologically active compounds with high
potential for therapeutic and biotechnological applications that can be used as prototypes for …

Gram-negative bacteria are becoming resistant to almost all currently available antibiotics.
Systemically designed antimicrobial peptides (AMPs) are attractive agents to enhance the …

Antimicrobial peptides (AMPs) are a potential solution to the increasing threat of antibiotic
resistance, but successful design of active but nontoxic AMPs requires understanding their …