AAV gene delivery to the spinal cord: serotypes, methods, candidate diseases, and clinical trials
Introduction: Adeno-associated viral (AAV) vector-mediated gene delivery to the spinal cord
has finally entered the pathway towards regulatory approval. Phase 1 clinical trials using …
has finally entered the pathway towards regulatory approval. Phase 1 clinical trials using …
Respiratory training and plasticity after cervical spinal cord injury
While spinal cord injuries (SCIs) result in a vast array of functional deficits, many of which
are life threatening, the majority of SCIs are anatomically incomplete. Spared neural …
are life threatening, the majority of SCIs are anatomically incomplete. Spared neural …
Novel regenerative drug, SPG302 promotes functional recovery of diaphragm muscle activity after cervical spinal cord injury
Spinal cord hemisection at C2 (C2SH), sparing the dorsal column is widely used to
investigate the effects of reduced phrenic motor neuron (PhMN) activation on diaphragm …
investigate the effects of reduced phrenic motor neuron (PhMN) activation on diaphragm …
Acute intrathecal BDNF enhances functional recovery after cervical spinal cord injury in rats
GC Sieck, HM Gransee, WZ Zhan… - Journal of …, 2021 - journals.physiology.org
Unilateral C2 hemisection (C2SH) disrupts descending inspiratory-related drive to phrenic
motor neurons and thus, silences rhythmic diaphragm muscle (DIAm) activity. There is …
motor neurons and thus, silences rhythmic diaphragm muscle (DIAm) activity. There is …
Local BDNF delivery to the injured cervical spinal cord using an engineered hydrogel enhances diaphragmatic respiratory function
We developed an innovative biomaterial-based approach to repair the critical neural
circuitry that controls diaphragm activation by locally delivering brain-derived neurotrophic …
circuitry that controls diaphragm activation by locally delivering brain-derived neurotrophic …
Impacts of epidural electrical stimulation on Wnt signaling, FAAH, and BDNF following thoracic spinal cord injury in rat
M Ghorbani, P Shahabi, P Karimi… - Journal of Cellular …, 2020 - Wiley Online Library
Electrical stimulation (ES) has been shown to improve some of impairments after spinal cord
injury (SCI), but the underlying mechanisms remain unclear. The Wnt signaling pathways …
injury (SCI), but the underlying mechanisms remain unclear. The Wnt signaling pathways …
Diaphragm electromyographic activity following unilateral midcervical contusion injury in rats
Contusion-type injuries to the spinal cord are characterized by tissue loss and disruption of
spinal pathways. Midcervical spinal cord injuries impair the function of respiratory muscles …
spinal pathways. Midcervical spinal cord injuries impair the function of respiratory muscles …
BDNF effects on functional recovery across motor behaviors after cervical spinal cord injury
V Hernandez-Torres, HM Gransee… - Journal of …, 2017 - journals.physiology.org
Unilateral C2 cervical spinal cord hemisection (SH) disrupts descending excitatory drive to
phrenic motor neurons, thereby paralyzing the ipsilateral diaphragm muscle (DIAm) during …
phrenic motor neurons, thereby paralyzing the ipsilateral diaphragm muscle (DIAm) during …
Phrenic motor neuron survival below cervical spinal cord hemisection
LL Allen, NL Nichols, ZA Asa, AT Emery… - Experimental …, 2021 - Elsevier
Cervical spinal cord injury (cSCI) severs bulbospinal projections to respiratory motor
neurons, paralyzing respiratory muscles below the injury. C2 spinal hemisection (C2Hx) is a …
neurons, paralyzing respiratory muscles below the injury. C2 spinal hemisection (C2Hx) is a …
BDNF-TrkB Signaling Pathway in Spinal Cord Injury: Insights and Implications
HS Shamsnia, A Peyrovinasab, D Amirlou… - Molecular …, 2024 - Springer
Spinal cord injury (SCI) is a neurodegenerative disorder that has critical impact on patient's
life expectance and life span, and this disorder also leads to negative socioeconomic …
life expectance and life span, and this disorder also leads to negative socioeconomic …