The extracellular matrix (ECM) is the complex meshwork of proteins and glycans that forms
the scaffold that surrounds and supports cells. It exerts key roles in all aspects of metazoan …

Protein glycosylation involves the co-translational or post-translational addition of glycans to
proteins and is a crucial protein modification in health and disease. The aim of …

Genomic analyses in cancer have been enormously impactful, leading to the identification of
driver mutations and development of targeted therapies. But the functions of the vast majority …

Peptide identification in liquid chromatography-tandem mass spectrometry (LC-MS/MS)
experiments relies on computational algorithms for matching acquired MS/MS spectra …

Post-translational modification (PTM) of antigens provides an additional source of
specificities targeted by immune responses to tumors or pathogens, but identifying antigen …

Identification of post-translationally or chemically modified peptides in mass spectrometry-
based proteomics experiments is a crucial yet challenging task. We have recently introduced …

Post-translational modifications are an area of great interest in mass spectrometry-based
proteomics, with a surge in methods to detect them in recent years. However, post …

Post-translational modification (PTM) of proteins allows cells to regulate protein functions,
transduce signals and respond to perturbations. PTMs expand protein functionality and …

Glycopeptides with unusual glycans or poor peptide backbone fragmentation in tandem
mass spectrometry are unaccounted for in typical site-specific glycoproteomics analysis and …

Robust, efficient, and reproducible protein extraction and sample processing is a key step for
bottom-up proteomics analyses. While many sample preparation protocols for mass …