Emerging roles and functional mechanisms of PIWI-interacting RNAs

X Wang, A Ramat, M Simonelig, MF Liu - Nature Reviews Molecular …, 2023 - nature.com
PIWI-interacting RNAs (piRNAs) are a class of small non-coding RNAs that associate with
proteins of the PIWI clade of the Argonaute family. First identified in animal germ line cells …

PIWI-interacting RNAs: small RNAs with big functions

DM Ozata, I Gainetdinov, A Zoch, D O'Carroll… - Nature Reviews …, 2019 - nature.com
In animals, PIWI-interacting RNAs (piRNAs) of 21–35 nucleotides in length silence
transposable elements, regulate gene expression and fight viral infection. piRNAs guide …

DEAD-box ATPases are global regulators of phase-separated organelles

M Hondele, R Sachdev, S Heinrich, J Wang… - Nature, 2019 - nature.com
The ability of proteins and nucleic acids to undergo liquid–liquid phase separation has
recently emerged as an important molecular principle of how cells rapidly and reversibly …

One loop to rule them all: the **-pong cycle and piRNA-guided silencing

B Czech, GJ Hannon - Trends in biochemical sciences, 2016 - cell.com
The PIWI-interacting RNA (piRNA) pathway is a conserved defense mechanism that protects
the genetic information of animal germ cells from the deleterious effects of molecular …

PIWI-interacting RNA: its biogenesis and functions

YW Iwasaki, MC Siomi, H Siomi - Annual review of biochemistry, 2015 - annualreviews.org
PIWI-interacting RNAs (piRNAs) are a class of small RNAs that are 24–31 nucleotides in
length. They associate with PIWI proteins, which constitute a germline-specific subclade of …

RISC assembly: Coordination between small RNAs and Argonaute proteins

H Kobayashi, Y Tomari - Biochimica et Biophysica Acta (BBA)-Gene …, 2016 - Elsevier
Non-coding RNAs generally form ribonucleoprotein (RNP) complexes with their partner
proteins to exert their functions. Small RNAs, including microRNAs, small interfering RNAs …

The exon junction complex as a node of post-transcriptional networks

HL Hir, J Saulière, Z Wang - Nature reviews Molecular cell biology, 2016 - nature.com
The exon junction complex (EJC) is deposited onto mRNAs following splicing and adopts a
unique structure, which can both stably bind to mRNAs and function as an anchor for diverse …

Identification of piRNA binding sites reveals the argonaute regulatory landscape of the C. elegans germline

EZ Shen, H Chen, AR Ozturk, S Tu, M Shirayama… - Cell, 2018 - cell.com
Summary piRNAs (Piwi-interacting small RNAs) engage Piwi Argonautes to silence
transposons and promote fertility in animal germlines. Genetic and computational studies …

From guide to target: molecular insights into eukaryotic RNA-interference machinery

JJ Ipsaro, L Joshua-Tor - Nature structural & molecular biology, 2015 - nature.com
Since its relatively recent discovery, RNA interference (RNAi) has emerged as a potent,
specific and ubiquitous means of gene regulation. Through a number of pathways that are …

Yeast Kre33 and human NAT10 are conserved 18S rRNA cytosine acetyltransferases that modify tRNAs assisted by the adaptor Tan1/THUMPD1

S Sharma, JL Langhendries, P Watzinger… - Nucleic acids …, 2015 - academic.oup.com
The function of RNA is subtly modulated by post-transcriptional modifications. Here, we
report an important crosstalk in the covalent modification of two classes of RNAs. We …