Prospective of 68Ga-radiopharmaceutical development
I Velikyan - Theranostics, 2013 - pmc.ncbi.nlm.nih.gov
Positron Emission Tomography (PET) experienced accelerated development and has
become an established method for medical research and clinical routine diagnostics on …
become an established method for medical research and clinical routine diagnostics on …
PET radiopharmaceuticals for imaging of tumor hypoxia: a review of the evidence
Hypoxia is a pathological condition arising in living tissues when oxygen supply does not
adequately cover the cellular metabolic demand. Detection of this phenomenon in tumors is …
adequately cover the cellular metabolic demand. Detection of this phenomenon in tumors is …
The ubiquitous DOTA and its derivatives: the impact of 1, 4, 7, 10-tetraazacyclododecane-1, 4, 7, 10-tetraacetic acid on biomedical imaging
Over the last twenty-five years 1, 4, 7, 10-tetraazacyclododecane-1, 4, 7, 10-tetraacetic acid
(DOTA) has made a significant impact on the field of diagnostic imaging. DOTA is not the …
(DOTA) has made a significant impact on the field of diagnostic imaging. DOTA is not the …
Advances in PET and MRI imaging of tumor hypoxia
Tumor hypoxia is a complex and evolving phenomenon both in time and space. Molecular
imaging allows to approach these variations, but the tracers used have their own limitations …
imaging allows to approach these variations, but the tracers used have their own limitations …
Bifunctional gallium-68 chelators: Past, present, and future
P Spang, C Herrmann, F Roesch - Seminars in nuclear medicine, 2016 - Elsevier
This article reviews the development of bifunctional chelates for synthesising 68 Ga
radiopharmaceuticals. It structures the chelates into groups of macrocycles …
radiopharmaceuticals. It structures the chelates into groups of macrocycles …
Metal-based redox-responsive MRI contrast agents
Given their potential in a better characterization and diagnosis of major pathologies like
cancer or chronic inflammation, redox-activated Magnetic Resonance Imaging (MRI) probes …
cancer or chronic inflammation, redox-activated Magnetic Resonance Imaging (MRI) probes …
Longitudinal PET imaging of tumor hypoxia during the course of radiotherapy
Hypoxia results from an imbalance between oxygen supply and consumption. It is a
common phenomenon in solid malignant tumors such as head and neck cancer. As hypoxic …
common phenomenon in solid malignant tumors such as head and neck cancer. As hypoxic …
Redox‐and hypoxia‐responsive MRI contrast agents
The development of responsive or “smart” magnetic resonance imaging (MRI) contrast
agents that can report specific biomarker or biological events has been the focus of MRI …
agents that can report specific biomarker or biological events has been the focus of MRI …
Scandium-44: diagnostic feasibility in tumor-related angiogenesis
Angiogenesis-related cell-surface molecules, including integrins, aminopeptidase N,
vascular endothelial growth factor, and gastrin-releasing peptide receptor (GRPR), play a …
vascular endothelial growth factor, and gastrin-releasing peptide receptor (GRPR), play a …
Molecular imaging of tumor hypoxia: Evolution of nitroimidazole radiopharmaceuticals and insights for future development
S Mittal, MB Mallia - Bioorganic Chemistry, 2023 - Elsevier
Though growing evidence has been collected in support of the concept of dose escalation
based on the molecular level images indicating hypoxic tumor sub-volumes that could be …
based on the molecular level images indicating hypoxic tumor sub-volumes that could be …