Human germ cell tumors are developmental cancers: impact of epigenetics on pathobiology and clinic
Current (high throughput omics-based) data support the model that human (malignant) germ
cell tumors are not initiated by somatic mutations, but, instead through a defined locked …
cell tumors are not initiated by somatic mutations, but, instead through a defined locked …
Oxidative stress and alterations in DNA methylation: two sides of the same coin in reproduction
YJR Menezo, E Silvestris, B Dale, K Elder - Reproductive biomedicine …, 2016 - Elsevier
The negative effect of oxidative stress on the human reproductive process is no longer a
matter for debate. Oxidative stress affects female and male gametes and the developmental …
matter for debate. Oxidative stress affects female and male gametes and the developmental …
STAG mutations in cancer
Stromal Antigen 1 and 2 (STAG1/2) are key subunits of the cohesin complex that mediate
sister chromatid cohesion, DNA repair, transcriptional regulation, and genome topology …
sister chromatid cohesion, DNA repair, transcriptional regulation, and genome topology …
Epigenetic drugs and their molecular targets in testicular germ cell tumours
S Jostes, D Nettersheim, H Schorle - Nature Reviews Urology, 2019 - nature.com
Current treatment regimens for type II testicular germ cell tumours (TGCTs) achieve cure
rates of≥ 95%; however, 1–5% of TGCTs develop resistance to standard platinum-based …
rates of≥ 95%; however, 1–5% of TGCTs develop resistance to standard platinum-based …
[HTML][HTML] Epigenetics and testicular germ cell tumors
Malignant testicular germ cell tumors (TGCTs) are the most frequent testicular cancers in
Caucasian males, develo** at the most productive age of man. We are briefly reviewing …
Caucasian males, develo** at the most productive age of man. We are briefly reviewing …
The epigenetics of testicular germ cell tumors: Looking for novel disease biomarkers
Testicular germ cell tumors (TGCT) are a group of heterogeneous, biologically diverse and
clinically challenging neoplasms. Despite the relatively low incidence and mortality rates, a …
clinically challenging neoplasms. Despite the relatively low incidence and mortality rates, a …
Role of USP13 in physiology and diseases
Q Wang, Z Sun, W **a, L Sun, Y Du… - Frontiers in Molecular …, 2022 - frontiersin.org
Ubiquitin specific protease (USP)-13 is a deubiquitinase that removes ubiquitin from
substrates to prevent protein degradation by the proteasome. Currently, the roles of USP13 …
substrates to prevent protein degradation by the proteasome. Currently, the roles of USP13 …
Epigenetic regulation of driver genes in testicular tumorigenesis
FE von Eyben, K Kristiansen, DS Kapp, R Hu… - International Journal of …, 2023 - mdpi.com
In testicular germ cell tumor type II (TGCT), a seminoma subtype expresses an induced
pluripotent stem cell (iPSC) panel with four upregulated genes, OCT4/POU5F1, SOX17 …
pluripotent stem cell (iPSC) panel with four upregulated genes, OCT4/POU5F1, SOX17 …
Differential methylation EPIC analysis discloses cisplatin-resistance related hypermethylation and tumor-specific heterogeneity within matched primary and metastatic …
J Lobo, V Constâncio, P Leite-Silva, R Guimarães… - Clinical …, 2021 - Springer
Testicular germ cell tumors (TGCTs) are among the most common solid malignancies in
young-adult men, and currently most mortality is due to metastatic disease and emergence …
young-adult men, and currently most mortality is due to metastatic disease and emergence …
Gene-vegetarianism interactions in calcium, estimated glomerular filtration rate, and testosterone identified in genome-wide analysis across 30 biomarkers
We examined the associations of vegetarianism with metabolic biomarkers using traditional
and genetic epidemiology. First, we addressed inconsistencies in self-reported …
and genetic epidemiology. First, we addressed inconsistencies in self-reported …