Abstract The hormone melatonin (5-methoxy-N-acetyltryptamine) is synthesized primarily in
the pineal gland and retina, and in several peripheral tissues and organs. In the circulation …

Melatonin MT1 and MT2 receptor ligands have been vigorously explored for the last 4
decades. Inspection of approximately 80 publications in the field revealed that most …

We explore the question of what are the best ligands for macromolecular targets. A survey of
experimental data on a large number of the strongest-binding ligands indicates that the free …

Melatonin receptors MT1 and MT2 are G protein-coupled receptors that mediate the effects
of melatonin, a hormone involved in circadian rhythms and other physiological functions …

6 H-Isoindolo [2, 1-a] indoles (5, 7, 10, 13), 5, 6-dihydroindolo [2, 1-a] isoquinolines (20, 21),
and 6, 7-dihydro-5 H-benzo [c] azepino [2, 1-a] indoles (23, 25, 27, 30) have been prepared …

Melatonin is a natural hormone primarily released by the pineal gland that regulates the
sleep-wake cycles. The diverse biological applications of melatonin, together with the need …

Heteroatom‐facilitated lithiation reactions have assumed an increasingly important role in
the elaboration of carbocyclic aromatic and heteroaromatic systems in the 40 years …

Discovering the mechanisms by which cell signaling controls the cell cycle of the human
malaria parasite Plasmodium falciparum is fundamental to designing more effective …

In this review we summarized the actual clinical data for a cardioprotective therapeutic role
of melatonin, listed melatonin and its agonists in different stages of development, and …

Melatonin plays different physiological functions ranging from the regulation of circadian
rhythms to tumor inhibition, owing to its antioxidant, immunomodulatory and anti-aging …