Obesity and cancer: mechanistic insights from transdisciplinary studies
Obesity is associated with a range of health outcomes that are of clinical and public health
significance, including cancer. Herein, we summarize epidemiologic and preclinical …
significance, including cancer. Herein, we summarize epidemiologic and preclinical …
Concise review: prostate cancer stem cells: current understanding
Prostate cancer (PCa) is heterogeneous, harboring phenotypically diverse cancer cell types.
PCa cell heterogeneity is caused by genomic instability that leads to the clonal competition …
PCa cell heterogeneity is caused by genomic instability that leads to the clonal competition …
[HTML][HTML] Combination of hypoglycemia and metformin impairs tumor metabolic plasticity and growth by modulating the PP2A-GSK3β-MCL-1 axis
Tumor cells may adapt to metabolic challenges by alternating between glycolysis and
oxidative phosphorylation (OXPHOS). To target this metabolic plasticity, we combined …
oxidative phosphorylation (OXPHOS). To target this metabolic plasticity, we combined …
[HTML][HTML] GLS-driven glutamine catabolism contributes to prostate cancer radiosensitivity by regulating the redox state, stemness and ATG5-mediated autophagy
Radiotherapy is one of the curative treatment options for localized prostate cancer (PCa).
The curative potential of radiotherapy is mediated by irradiation-induced oxidative stress …
The curative potential of radiotherapy is mediated by irradiation-induced oxidative stress …
Regulation of tumor cell migration and invasion by the H19/let-7 axis is antagonized by metformin-induced DNA methylation
The imprinted, developmentally regulated H19 long noncoding RNA has been implicated in
the pathogenesis of diverse human cancers, but the underlying mechanisms have remained …
the pathogenesis of diverse human cancers, but the underlying mechanisms have remained …
Metformin use and prostate cancer risk
Background Metformin may decrease prostate cancer (PCa) risk by reducing
hyperinsulinemia-associated carcinogenesis or through direct effects on cancer cells …
hyperinsulinemia-associated carcinogenesis or through direct effects on cancer cells …
Paradoxic effects of metformin on endothelial cells and angiogenesis
The biguanide metformin is used in type 2 diabetes management and has gained significant
attention as a potential cancer preventive agent. Angioprevention represents a mechanism …
attention as a potential cancer preventive agent. Angioprevention represents a mechanism …
Effects of metformin and phenformin on apoptosis and epithelial‐mesenchymal transition in chemoresistant rectal cancer
Recurrence and chemoresistance in colorectal cancer remain important issues for patients
treated with conventional therapeutics. Metformin and phenformin, previously used in the …
treated with conventional therapeutics. Metformin and phenformin, previously used in the …
Regulation and role of CAMKK2 in prostate cancer
Abstract In 2011, CAMKK2, the gene encoding calcium/calmodulin-dependent kinase
kinase 2 (CAMKK2), was demonstrated to be a direct target of the androgen receptor and a …
kinase 2 (CAMKK2), was demonstrated to be a direct target of the androgen receptor and a …
[HTML][HTML] Metformin repositioning as antitumoral agent: selective antiproliferative effects in human glioblastoma stem cells, via inhibition of CLIC1-mediated ion current
Metformin repositioning as antitumoral agent: selective antiproliferative effects in human
glioblastoma stem cells, via inhibition of CLIC1-mediated ion current - PMC Back to Top Skip to …
glioblastoma stem cells, via inhibition of CLIC1-mediated ion current - PMC Back to Top Skip to …