Structure and mechanism of human ABC transporters

A Alam, KP Locher - Annual Review of Biophysics, 2023 - annualreviews.org
ABC transporters are essential for cellular physiology. Humans have 48 ABC genes
organized into seven distinct families. Of these genes, 44 (in five distinct families) encode for …

The impact of sensory neuropathy and inflammation on epithelial wound healing in diabetic corneas

XY Fu-Shin, PSY Lee, L Yang, N Gao, Y Zhang… - Progress in retinal and …, 2022 - Elsevier
Diabetic peripheral neuropathy (DPN) is the most common complication of diabetes, with
several underlying pathophysiological mechanisms, some of which are still uncertain. The …

Progress in corneal wound healing

AV Ljubimov, M Saghizadeh - Progress in retinal and eye research, 2015 - Elsevier
Corneal wound healing is a complex process involving cell death, migration, proliferation,
differentiation, and extracellular matrix remodeling. Many similarities are observed in the …

Cancer stem cell surface markers on normal stem cells

WT Kim, CJ Ryu - BMB reports, 2017 - pmc.ncbi.nlm.nih.gov
The cancer stem cell (CSC) hypothesis has captured the attention of many scientists. It is
believed that elimination of CSCs could possibly eradicate the whole cancer. CSC surface …

[HTML][HTML] Innate immune system activation, inflammation and corneal wound healing

N Fortingo, S Melnyk, SH Sutton, MA Watsky… - International journal of …, 2022 - mdpi.com
Corneal wounds resulting from injury, surgeries, or other intrusions not only cause pain, but
also can predispose an individual to infection. While some inflammation may be beneficial to …

[HTML][HTML] The pathobiology of skin aging: new insights into an old dilemma

E Russell-Goldman, GF Murphy - The American journal of pathology, 2020 - Elsevier
Long considered both physiologic and inevitable, skin aging is a degenerative phenomenon
whereby both intrinsic and environmental factors conspire to produce an authentic disease …

Stem cells applications in regenerative medicine and disease therapeutics

RS Mahla - International journal of cell biology, 2016 - Wiley Online Library
Regenerative medicine, the most recent and emerging branch of medical science, deals
with functional restoration of tissues or organs for the patient suffering from severe injuries or …

Regenerating eye tissues to preserve and restore vision

JH Stern, Y Tian, J Funderburgh, G Pellegrini, K Zhang… - Cell stem cell, 2018 - cell.com
Ocular regenerative therapies are on track to revolutionize treatment of numerous blinding
disorders, including corneal disease, cataract, glaucoma, retinitis pigmentosa, and age …

ABC transporters and the hallmarks of cancer: roles in cancer aggressiveness beyond multidrug resistance

W Muriithi, LW Macharia, CP Heming… - Cancer biology & …, 2020 - cancerbiomed.org
The ATP-binding cassette transporters (ABC transporters) have been intensely studied over
the past 50 years for their involvement in the multidrug resistance (MDR) phenotype …

[HTML][HTML] Simple limbal epithelial transplantation: long-term clinical outcomes in 125 cases of unilateral chronic ocular surface burns

S Basu, SP Sureka, SS Shanbhag, AR Kethiri, V Singh… - Ophthalmology, 2016 - Elsevier
Purpose This study describes the long-term clinical outcomes of autologous simple limbal
epithelial transplantation (SLET), a relatively new technique of limbal stem cell …