The discovery of the Janus kinase (JAK)-signal transducer and activator of transcription
(STAT) pathway arose from investigations of how cells respond to interferons (IFNs) …

Type I interferons (IFNs) activate intracellular antimicrobial programmes and influence the
development of innate and adaptive immune responses. Canonical type I IFN signalling …

Cells maintain the balance between homeostasis and inflammation by adapting and
integrating the activity of intracellular signaling cascades, including the JAK-STAT pathway …

Abstract RNA polymerase II (Pol II) apparatuses are compartmentalized into transcriptional
clusters. Whether protein factors control these clusters remains unknown. In this study, we …

Pontin (RUVBL1, TIP49, TIP49a, Rvb1) and Reptin (RUVBL2, TIP48, TIP49b, Rvb2) are
highly conserved ATPases of the AAA+ (ATPases Associated with various cellular Activities) …

Sensing invading pathogens early in infection is critical for establishing host defense. Two
cytosolic RIG-like RNA helicases, RIG-I and MDA5, are key to type I interferon (IFN) …

In response to virus infections, a cell-autonomous, transcription-based antiviral program is
engaged to create resistance, impair pathogen replication, and alert professional cells in …

IFNs are cytokines with important antiproliferative activity and exhibit key roles in immune
surveillance against malignancies. Early work initiated over three decades ago led to the …

The type I interferon (IFN) response is a crucial innate immune signalling pathway required
for defense against viral infection. Accordingly, the great majority of mammalian viruses …

This study evaluates the role of the late viral protein, pA104R, in African swine fever virus
immunosuppression. ASFV-encoded pA104R is a putative histone-like protein that is highly …