Two of the most prevalent human viruses worldwide, herpes simplex virus type 1 and type 2
(HSV-1 and HSV-2, respectively), cause a variety of diseases, including cold sores, genital …

SUMMARY Herpes simplex virus 1 (HSV-1) is very successful in establishing acute and
latent infections in humans by counteracting host antiviral innate immune responses. HSV-1 …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes coronavirus
disease 2019 (COVID-19), has seriously threatened global public health. Severe COVID-19 …

Pseudorabies virus (PRV) has evolved various immune evasion mechanisms that target
host antiviral immune responses. However, it is unclear whether and how PRV encoded …

The interferon regulatory factor (IRF) family of transcription factors play a vital role in the
human innate antiviral immune responses with production of interferons (IFNs) as a hallmark …

Alphaherpesviruses (α-HV) are a large family of double-stranded DNA viruses which cause
many human and animal diseases. There are three human α-HVs: Herpes Simplex Viruses …

African swine fever (ASF) is a devastating infectious disease caused by African swine fever
virus (ASFV). The ASFV genome encodes multiple structural and non-structural proteins that …

The interferon (IFN) system is one of the first lines of defense activated against invading viral
pathogens. Upon secretion, IFNs activate a signaling cascade resulting in the production of …

Abstract Cyclic GMP-AMP synthase (cGAS) is a major DNA sensor. The recognition of
cytosolic DNA by cGAS triggers a robust innate immune response that restricts the …

Innate immune mechanisms initiate immune responses via pattern-recognition receptors
(PRRs). Cyclic GMP-AMP synthase (cGAS), a member of the PRRs, senses diverse …