It is well established that the vast majority of human RNA transcripts do not encode for
proteins and that non-coding RNAs regulate cell physiology and shape cellular functions. A …

Some of the biological knowledge obtained from fundamental research will be implemented
in applied plant breeding. To bridge basic research and breeding practice, machine learning …

Respiratory failure is the leading cause of death in patients with severe SARS-CoV-2
infection,, but the host response at the lung tissue level is poorly understood. Here we …

Fibrotic skin disease represents a major global healthcare burden, characterized by
fibroblast hyperproliferation and excessive accumulation of extracellular matrix. Fibroblasts …

In a human menstrual cycle the endometrium undergoes remodeling, shedding and
regeneration, all of which are driven by substantial gene expression changes in the …

Cancer-associated fibroblasts (CAF) are major players in the progression and drug
resistance of pancreatic ductal adenocarcinoma (PDAC). CAFs constitute a diverse cell …

Clear cell renal carcinoma (ccRCC) is a heterogeneous disease with a variable post-
surgical course. To assemble a comprehensive ccRCC tumor microenvironment (TME) …

Mutual information (MI) minimization has gained considerable interests in various machine
learning tasks. However, estimating and minimizing MI in high-dimensional spaces remains …

Identifying the transcription factors (TFs) responsible for observed changes in gene
expression is an important step in understanding gene regulatory networks. ChIP-X …

Melanoma brain metastasis (MBM) frequently occurs in patients with advanced melanoma;
yet, our understanding of the underlying salient biology is rudimentary. Here, we performed …