Nanopore Sequencing of the Pharmacogene CYP2D6 Allows Simultaneous Haploty** and Detection of Duplications
Aim: Long read sequencing offers the promise of overcoming some of the challenges in
accurate genoty** of complex genes, along with the advantage of straightforward variant …
accurate genoty** of complex genes, along with the advantage of straightforward variant …
Omeprazole Treatment Failure in Gastroesophageal Reflux Disease and Genetic Variation at the CYP2C Locus
Omeprazole is extensively used to manage gastroesophageal reflux disease (GERD). It is
primarily metabolized by CYP2C19. The CYP2C19* 17 (rs12248560) allele and the recently …
primarily metabolized by CYP2C19. The CYP2C19* 17 (rs12248560) allele and the recently …
The history and future of pharmacogenetics in Aotearoa/New Zealand
MA Kennedy - Journal of the Royal Society of New Zealand, 2024 - Taylor & Francis
Pharmacogenetics is the study of genetic variants in genes which may impact on the
outcome of drug treatment, either through safety considerations (occurrence of adverse drug …
outcome of drug treatment, either through safety considerations (occurrence of adverse drug …
The pharmacogenetics of CYP2D6 and CYP2C19 in a case series of antidepressant responses
Pharmacogenetics has potential for optimizing use of psychotropics. CYP2D6 and
CYP2C19 are two clinically relevant pharmacogenes in the prescribing of antidepressants …
CYP2C19 are two clinically relevant pharmacogenes in the prescribing of antidepressants …
Metoclopramide-induced acute dystonic reactions may be associated with the CYP2D6 poor metabolizer status and pregnancy-related hormonal changes
We report two cases of metoclopramide-induced acute dystonia in pregnant women and
consider the role of genetic variation in the pathogenesis of the adverse effect. By whole …
consider the role of genetic variation in the pathogenesis of the adverse effect. By whole …
[HTML][HTML] Epidemiology of severe cutaneous adverse drug reaction and its HLA association among pediatrics
Severe cutaneous adverse drug reaction (SCAR) is considered to be a multifactorial drug
side effect. This study was designed to investigate the epidemiology and human leukocyte …
side effect. This study was designed to investigate the epidemiology and human leukocyte …
Multiplexed nanopore sequencing of HLA-B locus in Māori and Pacific Island samples
KNT Ton, SL Cree, SJ Gronert-Sum… - Frontiers in …, 2018 - frontiersin.org
The human leukocyte antigen (HLA) system encodes the human major histocompatibility
complex (MHC). HLA-B is the most polymorphic gene in the MHC class I region and many …
complex (MHC). HLA-B is the most polymorphic gene in the MHC class I region and many …
Decision tree-based expert system for adverse drug reaction detection using fuzzy logic and genetic algorithm
AM Mansour - International Journal of Advanced Computer …, 2018 - search.proquest.com
Early detection of unknown adverse drug reactions (ADRs) could save patient lives and
prevent unnecessary hospitalizations. Current surveillance systems are not ideal for rapidly …
prevent unnecessary hospitalizations. Current surveillance systems are not ideal for rapidly …
The three ps: Psychiatry, pharmacy, and pharmacogenomics, a brief report from New Zealand
We describe a case series of 22 individuals who were referred to our laboratory by a
pharmacist based in a mental health hospital, for pharmacogenetic analysis due to severe or …
pharmacist based in a mental health hospital, for pharmacogenetic analysis due to severe or …
Age and Gender-Dependent Comorbidities in UAE Population identifies Coronary Artery Disease with Gene-Environment Interactions
H Iftikhar - medRxiv, 2025 - medrxiv.org
This study investigated the age and sex-dependent comorbidities contributing to coronary
artery disease (CAD) within the UAE population. A cohort of 3,000 individuals was analyzed …
artery disease (CAD) within the UAE population. A cohort of 3,000 individuals was analyzed …