Recent progress of solid lipid nanoparticles and nanostructured lipid carriers as ocular drug delivery platforms

V Gugleva, V Andonova - Pharmaceuticals, 2023 - mdpi.com
Sufficient ocular bioavailability is often considered a challenge by the researchers, due to
the complex structure of the eye and its protective physiological mechanisms. In addition, the …

Formulation of hesperidin‐loaded in situ gel for ocular drug delivery: a comprehensive study

S Gözcü, HK Polat, Y Gültekin, S Ünal… - Journal of the …, 2024 - Wiley Online Library
BACKGROUND Allergic conjunctivitis is one of the most common eye disorders. Different
drugs are used for its treatment. Hesperidin is an active substance isolated from Citrus …

A comparative study between nanostructured lipid carriers and invasomes for the topical delivery of luteolin: design, optimization and pre-clinical investigations for …

M El-Kayal, S Hatem - Journal of Drug Delivery Science and Technology, 2024 - Elsevier
Psoriasis is an inflammatory skin condition manifested by hyper-proliferation and reactive
aberrant epidermal differentiation, in which genetic and environmental factors have a …

[HTML][HTML] Development of ciprofloxacin-loaded bilosomes in-situ gel for ocular delivery: optimization, in-vitro characterization, ex-vivo permeation, and antimicrobial …

OA Alsaidan, A Zafar, M Yasir, SI Alzarea, M Alqinyah… - Gels, 2022 - mdpi.com
Conventional eye drops are most commonly employed topically in the eye for the
management of bacterial conjunctivitis. Eye drops have a low corneal residence time and 90 …

[HTML][HTML] Novel anti-psoriatic nanostructured lipid carriers for the cutaneous delivery of luteolin: A comprehensive in-vitro and in-vivo evaluation

S Hatem, M El-Kayal - European Journal of Pharmaceutical Sciences, 2023 - Elsevier
Psoriasis is a prevalent laborious inflammation in skin with alternate phases of remission
and relapses. The current study sought to develop nanostructured lipid carriers (NLCs) …

Harnessing silk fibroin microparticles for metformin delivery: A novel approach to treating corneal neovascularization

HK Polat, E Aytekin, NF Karakuyu, YA Çaylı… - Journal of Drug Delivery …, 2024 - Elsevier
Corneal neovascularization (CV) poses significant challenges in ophthalmology, often
leading to impaired vision and discomfort. Silk fibroin microparticles have emerged as …

Formulation development of Lornoxicam loaded heat triggered ocular in-situ gel using factorial design

HK Polat, S Ünal, E Aytekin, NF Karakuyu… - Drug Development …, 2023 - Taylor & Francis
Objective In the current research, lornoxicam-loaded in situ gels were developed, and their
potential usage in ocular inflammation was evaluated. Significance Lornoxicam cyclodextrin …

[HTML][HTML] Besifloxacin nanocrystal: towards an innovative ophthalmic preparation

JISS Jesus, FR Lourenço, K Ishida, TL Barreto… - Pharmaceutics, 2022 - mdpi.com
Bacterial conjunctivitis significantly impacts public health, including more than one-third of
eye diseases reported worldwide. It is an infection caused by various aerobic and anaerobic …

Formulation Development of Dual Drug-Loaded Thermosensitive Ocular In Situ Gel Using Factorial Design

HK Polat, A Arslan, S Ünal, MK Haydar… - Journal of …, 2023 - Springer
Purpose To overcome the problems of low bioavailability of the drug associated with the
short pre-corneal residence time, a thermoresponsive in situ gel system containing …

Thermosensitive in situ gelling system for dermal drug delivery of rutin

S Gözcü, KH Polat - Turkish Journal of Pharmaceutical …, 2023 - pmc.ncbi.nlm.nih.gov
Objectives: Rutin has been broadly applied for treating several diseases due to its
pharmacological activities. However, its low aqueous solubility limits its absorption and …