SCFA: mechanisms and functional importance in the gut

C Martin-Gallausiaux, L Marinelli… - Proceedings of the …, 2021 - cambridge.org
In recent years, the importance of the gut microbiota in human health has been revealed and
many publications have highlighted its role as a key component of human physiology …

Role of gut microbiota in infectious and inflammatory diseases

MF Maciel-Fiuza, GC Muller, DMS Campos… - Frontiers in …, 2023 - frontiersin.org
Thousands of microorganisms compose the human gut microbiota, fighting pathogens in
infectious diseases and inhibiting or inducing inflammation in different immunological …

Gut dysbiosis: Ecological causes and causative effects on human disease

SE Winter, AJ Bäumler - Proceedings of the National Academy of …, 2023 - pnas.org
The gut microbiota plays a role in many human diseases, but high-throughput sequence
analysis does not provide a straightforward path for defining healthy microbial communities …

Enhancement of the gut barrier integrity by a microbial metabolite through the Nrf2 pathway

R Singh, S Chandrashekharappa, SR Bodduluri… - Nature …, 2019 - nature.com
The importance of gut microbiota in human health and pathophysiology is undisputable.
Despite the abundance of metagenomics data, the functional dynamics of gut microbiota in …

Metabolic networks in mutant KRAS-driven tumours: tissue specificities and the microenvironment

SA Kerk, T Papagiannakopoulos, YM Shah… - Nature Reviews …, 2021 - nature.com
Oncogenic mutations in KRAS drive common metabolic programmes that facilitate tumour
survival, growth and immune evasion in colorectal carcinoma, non-small-cell lung cancer …

Colonocyte metabolism shapes the gut microbiota

Y Litvak, MX Byndloss, AJ Bäumler - Science, 2018 - science.org
BACKGROUND An imbalance in the colonic microbiota might underlie many human
diseases, but the mechanisms that balance our microbial self during homeostasis have long …

[HTML][HTML] Oxygen battle in the gut: Hypoxia and hypoxia-inducible factors in metabolic and inflammatory responses in the intestine

R Singhal, YM Shah - Journal of Biological Chemistry, 2020 - Elsevier
The gastrointestinal tract is a highly proliferative and regenerative tissue. The intestine also
harbors a large and diverse microbial population collectively called the gut microbiome …

Microbiota-activated PPAR-γ signaling inhibits dysbiotic Enterobacteriaceae expansion

MX Byndloss, EE Olsan, F Rivera-Chávez, CR Tiffany… - Science, 2017 - science.org
Perturbation of the gut-associated microbial community may underlie many human illnesses,
but the mechanisms that maintain homeostasis are poorly understood. We found that the …

Diet fuelling inflammatory bowel diseases: preclinical and clinical concepts

TE Adolph, J Zhang - Gut, 2022 - gut.bmj.com
The diet and gut microbiota have been extensively interrogated as a fuel for gut
inflammation in inflammatory bowel diseases (IBDs) in the last few years. Here, we review …

Dysbiotic Proteobacteria expansion: a microbial signature of epithelial dysfunction

Y Litvak, MX Byndloss, RM Tsolis… - Current opinion in …, 2017 - Elsevier
Highlights•Epithelial hypoxia drives anaerobiosis to maintain dominance of obligate
anaerobes.•Increased epithelial oxygenation disrupts anaerobiosis in the large …