Basal cell carcinoma (BCC) is the most common cancer in white‐skinned individuals with
increasing incidence rates worldwide. Patients with BCC place a large burden on healthcare …

The glutathione S-transferases (GST) represent a major group of detoxification enzymes. All
eukaryotic species possess multiple cytosolic and membrane-bound GST isoenzymes, each …

The loci encoding the glutathione-S-transferase (GST) enzymes comprise a large
supergene family located on at least seven chromosomes. The function of the GST enzymes …

The glutathione S-transferases (GST) are a supergene family of dimeric, enzymes that
catalyse the conjugation of glutathione (GSH) to a variety of electrophiles including arene …

The glutathione S-transferase (GST) supergene family comprises gene families that encode
isoenzymes that are widely expressed in mammalian tissue cytosols and membranes. Both …

A deletion polymorphism in glutathione S-transferase theta (GSTT1) gene was recently
discovered in humans. Similar to the GSTM1 gene, GSTT1 is also recognized as a risk …

Predisposition to melanoma is genetically heterogeneous. Two high penetrance
susceptibility genes, CDKN2A and CDK4, have so far been identified and map** is …

A partial physical map has been constructed of the human class Mu glutathione S-
transferase genes on chromosome 1p13. 3. The glutathione S-transferase genes in this …

Up to 90% of all cancers are possibly caused by environmental factors, such as tobacco
smoke, diet and occupational exposures. The majority of chemical carcinogens require …

It has become clear that several polymorphisms of human drug-metabolizing enzymes
influence an individual's susceptibility for chemical carcinogenesis. This review gives an …