Human topoisomerases and their roles in genome stability and organization
Human topoisomerases comprise a family of six enzymes: two type IB (TOP1 and
mitochondrial TOP1 (TOP1MT), two type IIA (TOP2A and TOP2B) and two type IA (TOP3A …
mitochondrial TOP1 (TOP1MT), two type IIA (TOP2A and TOP2B) and two type IA (TOP3A …
DNA topoisomerases: Advances in understanding of cellular roles and multi‐protein complexes via structure‐function analysis
DNA topoisomerases, capable of manipulating DNA topology, are ubiquitous and
indispensable for cellular survival due to the numerous roles they play during DNA …
indispensable for cellular survival due to the numerous roles they play during DNA …
Cell cycle-dependent control and roles of DNA topoisomerase II
JH Lee, JM Berger - Genes, 2019 - mdpi.com
Type II topoisomerases are ubiquitous enzymes in all branches of life that can alter DNA
superhelicity and unlink double-stranded DNA segments during processes such as …
superhelicity and unlink double-stranded DNA segments during processes such as …
Visualizing RNA polymers produced by hot wet-dry cycling
It is possible that the transition from abiotic systems to life relied on RNA polymers that
served as ribozyme-like catalysts and for storing genetic information. The source of such …
served as ribozyme-like catalysts and for storing genetic information. The source of such …
Pathological variants in TOP3A cause distinct disorders of mitochondrial and nuclear genome stability
D Erdinc, A Rodríguez‐Luis, MR Fassad… - EMBO Molecular …, 2023 - embopress.org
Abstract Topoisomerase 3α (TOP3A) is an enzyme that removes torsional strain and
interlinks between DNA molecules. TOP3A localises to both the nucleus and mitochondria …
interlinks between DNA molecules. TOP3A localises to both the nucleus and mitochondria …
Controlling the topology of mammalian mitochondrial DNA
The genome of mitochondria, called mtDNA, is a small circular DNA molecule present at
thousands of copies per human cell. MtDNA is packaged into nucleoprotein complexes …
thousands of copies per human cell. MtDNA is packaged into nucleoprotein complexes …
PICH acts as a force-dependent nucleosome remodeler
D Spakman, TVM Clement, AS Biebricher… - Nature …, 2022 - nature.com
In anaphase, any unresolved DNA entanglements between the segregating sister
chromatids can give rise to chromatin bridges. To prevent genome instability, chromatin …
chromatids can give rise to chromatin bridges. To prevent genome instability, chromatin …
Mechanical determinants of chromatin topology and gene expression
The compaction of linear DNA into micrometer-sized nuclear boundaries involves the
establishment of specific three-dimensional (3D) DNA structures complexed with histone …
establishment of specific three-dimensional (3D) DNA structures complexed with histone …
[HTML][HTML] Topoisomerases and cancer chemotherapy: Recent advances and unanswered questions
MA Bjornsti, SH Kaufmann - F1000Research, 2019 - ncbi.nlm.nih.gov
DNA topoisomerases are enzymes that catalyze changes in the torsional and flexural strain
of DNA molecules. Earlier studies implicated these enzymes in a variety of processes in both …
of DNA molecules. Earlier studies implicated these enzymes in a variety of processes in both …
The many lives of type IA topoisomerases
AH Bizard, ID Hickson - Journal of Biological Chemistry, 2020 - ASBMB
The double-helical structure of genomic DNA is both elegant and functional in that it serves
both to protect vulnerable DNA bases and to facilitate DNA replication and compaction …
both to protect vulnerable DNA bases and to facilitate DNA replication and compaction …