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The plasticity of mRNA translation during cancer progression and therapy resistance
Translational control of mRNAs during gene expression allows cells to promptly and
dynamically adapt to a variety of stimuli, including in neoplasia in response to aberrant …
dynamically adapt to a variety of stimuli, including in neoplasia in response to aberrant …
Role of the PI3K/AKT/mTOR signaling pathway in ovarian cancer: Biological and therapeutic significance
Ovarian cancer (OC) is a lethal gynecological cancer. The phosphatidylinositol 3-kinase
(PI3K)/AKT/mammalian target of rapamycin (mTOR) signaling pathway plays an important …
(PI3K)/AKT/mammalian target of rapamycin (mTOR) signaling pathway plays an important …
Bromodomain and extraterminal (BET) proteins: biological functions, diseases and targeted therapy
ZQ Wang, ZC Zhang, YY Wu, YN Pi, SH Lou… - Signal transduction and …, 2023 - nature.com
BET proteins, which influence gene expression and contribute to the development of cancer,
are epigenetic interpreters. Thus, BET inhibitors represent a novel form of epigenetic …
are epigenetic interpreters. Thus, BET inhibitors represent a novel form of epigenetic …
Role of PI3K-AKT-mTOR pathway as a pro-survival signaling and resistance-mediating mechanism to therapy of prostate cancer
Androgen deprivation therapy (ADT) and androgen receptor (AR)-targeted therapy are the
gold standard options for treating prostate cancer (PCa). These are initially effective, as …
gold standard options for treating prostate cancer (PCa). These are initially effective, as …
DNA damage and the balance between survival and death in cancer biology
WP Roos, AD Thomas, B Kaina - Nature Reviews Cancer, 2016 - nature.com
DNA is vulnerable to damage resulting from endogenous metabolites, environmental and
dietary carcinogens, some anti-inflammatory drugs, and genotoxic cancer therapeutics …
dietary carcinogens, some anti-inflammatory drugs, and genotoxic cancer therapeutics …
Kaempferol induces ROS-dependent apoptosis in pancreatic cancer cells via TGM2-mediated Akt/mTOR signaling
F Wang, L Wang, C Qu, L Chen, Y Geng, C Cheng… - BMC cancer, 2021 - Springer
Background Kaempferol, a natural flavonoid, exhibits anticancer properties by scavenging
reactive oxygen species (ROS). However, increasing evidence has demonstrated that …
reactive oxygen species (ROS). However, increasing evidence has demonstrated that …
[HTML][HTML] Obesity-induced TNFα and IL-6 signaling: the missing link between obesity and inflammation—driven liver and colorectal cancers
Cancers | Free Full-Text | Obesity-Induced TNFα and IL-6 Signaling: The Missing Link between
Obesity and Inflammation—Driven Liver and Colorectal Cancers Next Article in Journal Effects …
Obesity and Inflammation—Driven Liver and Colorectal Cancers Next Article in Journal Effects …
The organizing principles of eukaryotic ribosome recruitment
The stage at which ribosomes are recruited to messenger RNAs (mRNAs) is an elaborate
and highly regulated phase of protein synthesis. Upon completion of this step, a ribosome is …
and highly regulated phase of protein synthesis. Upon completion of this step, a ribosome is …
Targeting the translation machinery in cancer
Dysregulation of mRNA translation is a frequent feature of neoplasia. Many oncogenes and
tumour suppressors affect the translation machinery, making aberrant translation a …
tumour suppressors affect the translation machinery, making aberrant translation a …
Oncogenic roles of the PI3K/AKT/mTOR axis
M Aoki, T Fujishita - Viruses, genes, and cancer, 2017 - Springer
Abstract The PI3K/AKT/mTOR pathway is frequently activated in various human cancers and
has been considered a promising therapeutic target. Many of the positive regulators of the …
has been considered a promising therapeutic target. Many of the positive regulators of the …