Alcohol use disorder (AUD) is a widespread disease with limited treatment options.
Targeting the neuroimmune system is a new avenue for develo** or repurposing effective …

Studies using animal models of adolescent exposure to alcohol, nicotine, cannabinoids, and
the stimulants cocaine, 3, 4-methylenedioxymethampethamine and methamphetamine have …

JCI - Preclinical and clinical evidence for suppression of alcohol intake by apremilast Go to JCI
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The innate immune response in the central nervous system (CNS) participates in both
synaptic plasticity and neural damage. Emerging evidence from human and animal studies …

In recent years, some new processes have been proposed to explain how alcohol may
influence behavior, psychological symptoms and alcohol seeking in alcohol-dependent …

The gut-brain communication is mostly driven by the immune, metabolic and neural
pathways which remained poorly explored in patients with alcohol use disorder (AUD). The …

While the immune system is essential for survival, an excessive or prolonged inflammatory
response, such as that resulting from sustained heavy alcohol use, can damage the host …

Studies in humans and experimental animals have demonstrated the vulnerability of the
adolescent brain to actions of ethanol and the long-term consequences of binge drinking …

Microglia activation and neuroinflammation are common features of neurodegenerative
conditions, including alcohol use disorders (AUDs). When activated, microglia span a …

The epidemic of alcohol abuse affects millions of people worldwide. Relevant evidence
supports the notion that the gut microbiota (GM) plays a crucial role in central nervous …