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Interleukin-2 signaling in the regulation of T cell biology in autoimmunity and cancer
AN Shouse, KM LaPorte, TR Malek - Immunity, 2024 - cell.com
Summary Interleukin-2 (IL-2) is a critical cytokine for T cell peripheral tolerance and
immunity. Here, we review how IL-2 interaction with the high-affinity IL-2 receptor (IL-2R) …
immunity. Here, we review how IL-2 interaction with the high-affinity IL-2 receptor (IL-2R) …
Sustained AhR activity programs memory fate of early effector CD8+ T cells
H Zhang, Z Yang, W Yuan, J Liu, X Luo… - Proceedings of the …, 2024 - pnas.org
Identification of mechanisms that program early effector T cells to either terminal effector T
(Teff) or memory T (Tm) cells has important implications for protective immunity against …
(Teff) or memory T (Tm) cells has important implications for protective immunity against …
Immunomodulatory role of metalloproteinase ADAM17 in tumor development
K Wang, Z Xuan, X Liu, M Zheng, C Yang… - Frontiers in …, 2022 - frontiersin.org
ADAM17 is a member of the a disintegrin and metalloproteinase (ADAM) family of
transmembrane proteases involved in the shedding of some cell membrane proteins and …
transmembrane proteases involved in the shedding of some cell membrane proteins and …
Autocrine VEGF-B signaling maintains lipid synthesis and mitochondrial fitness to support T cell immune responses
J He, Y Chen, H Ding, JA Zhou, Z ** immunotherapies. The serine/threonine kinase hematopoietic progenitor …
Regulatory T-cell dysfunction and its implication for cell therapy
N Valentini, CJ Requejo Cier… - Clinical and …, 2023 - academic.oup.com
Regulatory T cells (Tregs) are a subtype of CD4+ T cells that can mediate immune tolerance
by a multitude of immunomodulatory mechanisms. Treg-based adoptive immunotherapy is …
by a multitude of immunomodulatory mechanisms. Treg-based adoptive immunotherapy is …