Integrative methods and practical challenges for single-cell multi-omics
Fast-develo** single-cell multimodal omics (scMulti-omics) technologies enable the
measurement of multiple modalities, such as DNA methylation, chromatin accessibility, RNA …
measurement of multiple modalities, such as DNA methylation, chromatin accessibility, RNA …
Development of therapeutic antibodies for the treatment of diseases
Z Wang, G Wang, H Lu, H Li, M Tang, A Tong - Molecular biomedicine, 2022 - Springer
Since the first monoclonal antibody drug, muromonab-CD3, was approved for marketing in
1986, 165 antibody drugs have been approved or are under regulatory review worldwide …
1986, 165 antibody drugs have been approved or are under regulatory review worldwide …
Human T-bet governs the generation of a distinct subset of CD11chighCD21low B cells
High-level expression of the transcription factor T-bet characterizes a phenotypically distinct
murine B cell population known as “age-associated B cells”(ABCs). T-bet–deficient mice …
murine B cell population known as “age-associated B cells”(ABCs). T-bet–deficient mice …
Refining colorectal cancer classification and clinical stratification through a single-cell atlas
Background Colorectal cancer (CRC) consensus molecular subtypes (CMS) have different
immunological, stromal cell, and clinicopathological characteristics. Single-cell …
immunological, stromal cell, and clinicopathological characteristics. Single-cell …
Bone marrow Adipoq-lineage progenitors are a major cellular source of M-CSF that dominates bone marrow macrophage development, osteoclastogenesis, and bone …
M-CSF is a critical growth factor for myeloid lineage cells, including monocytes,
macrophages, and osteoclasts. Tissue-resident macrophages in most organs rely on local M …
macrophages, and osteoclasts. Tissue-resident macrophages in most organs rely on local M …
Progress and challenges in mass spectrometry-based analysis of antibody repertoires
Humoral immunity is divided into the cellular B cell and protein-level antibody responses.
High-throughput sequencing has advanced our understanding of both these fundamental …
High-throughput sequencing has advanced our understanding of both these fundamental …
scRNA-seq revealed the special TCR β & α V (D) J allelic inclusion rearrangement and the high proportion dual (or more) TCR-expressing cells
L Zhu, Q Peng, J Li, Y Wu, J Wang, D Zhou, L Ma… - Cell Death & …, 2023 - nature.com
Allelic exclusion, one lymphocyte expresses one antigen receptor, is a fundamental
mechanism of immunological self-tolerance and highly specific immune responses to …
mechanism of immunological self-tolerance and highly specific immune responses to …
[HTML][HTML] A novel phenotype of B cells associated with enhanced phagocytic capability and chemotactic function after ischemic stroke
R Wang, H Li, C Ling, X Zhang, J Lu… - Neural Regeneration …, 2023 - journals.lww.com
Accumulating evidence has demonstrated the involvement of B cells in neuroinflammation
and neuroregeneration. However, the role of B cells in ischemic stroke remains unclear. In …
and neuroregeneration. However, the role of B cells in ischemic stroke remains unclear. In …
Global characterization of B cell receptor repertoire in COVID-19 patients by single-cell V (D) J sequencing
X **, W Zhou, M Luo, P Wang, Z Xu, K Ma… - Briefings in …, 2021 - academic.oup.com
The world is facing a pandemic of Corona Virus Disease 2019 (COVID-19) caused by
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Adaptive immune …
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Adaptive immune …
[HTML][HTML] Sex-based differences in effector cells of the adaptive immune system during Alzheimer's disease and related dementias
Neurological conditions such as Alzheimer's disease (AD) and related dementias (ADRD)
present with many challenges due to the heterogeneity of the related disease (s), making it …
present with many challenges due to the heterogeneity of the related disease (s), making it …