In solid tumours, cancer cells exist within hypoxic microenvironments, and their metabolic
adaptation to this hypoxia is driven by HIF-1 transcription factor, which is overexpressed in a …

There is wide evidence that CRC could be prevented by regular physical activity, kee** a
healthy body weight, and following a healthy and balanced diet. Many sporadic CRCs …

Currently, there is a crucial need for novel diagnostic and prognostic biomarkers with high
specificity and sensitivity in patients with colorectal cancer. A “liquid biopsy” is characterized …

Background: The leading cause of poor prognosis in colorectal cancer (CRC) is the
presence of colorectal cancer-initiating cells (CCICs). The interplay between the tumor …

Background Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast
cancer, with poor prognosis and limited treatment options. Hypoxia is a key hallmark of …

Membrane transporters including glucose transporters (GLUTs) are involved in cellular
energy supplies, cell metabolism and other vital biological activities. They have also been …

Metabolism differs significantly between tumor and normal cells. Metabolic reprogramming
in cancer cells and metabolic interplay in the tumor microenvironment (TME) are important …

Several studies have shown an inverse relationship between acute infections and cancer
development. On the other hand, there is a growing evidence that chronic infections may …

Standard cell culture is routinely performed at supraphysiological oxygen levels (~ 18% O2).
Conversely, O2 levels in most mammalian tissues range from 1–6%(physioxia). Such …

Patients with familial adenomatous polyposis (FAP), an autosomal dominant hereditary
colorectal cancer syndrome, have a lifetime risk of develo** cancer of nearly 100 …