Laminins in metabolic tissues
A Goddi, L Schroedl, EM Brey, RN Cohen - Metabolism, 2021 - Elsevier
Laminins are extracellular matrix proteins that reside in the basement membrane and
provide structural support in addition to promoting cellular adhesion and migration. Through …
provide structural support in addition to promoting cellular adhesion and migration. Through …
Laminin α4 deficient mice exhibit decreased capacity for adipose tissue expansion and weight gain
Obesity is a global epidemic that contributes to the increasing medical burdens related to
type 2 diabetes, cardiovascular disease and cancer. A better understanding of the …
type 2 diabetes, cardiovascular disease and cancer. A better understanding of the …
A conserved role for syndecan family members in the regulation of whole-body energy metabolism
Syndecans are a family of type-I transmembrane proteins that are involved in cell-matrix
adhesion, migration, neuronal development, and inflammation. Previous quantitative genetic …
adhesion, migration, neuronal development, and inflammation. Previous quantitative genetic …
Variation in extracellular matrix genes is associated with weight regain after weight loss in a sex-specific manner
NJT Roumans, RG Vink, M Gielen, MP Zeegers… - Genes & nutrition, 2015 - Springer
The extracellular matrix (ECM) of adipocytes is important for body weight regulation. Here,
we investigated whether genetic variation in ECM-related genes is associated with weight …
we investigated whether genetic variation in ECM-related genes is associated with weight …
Nuclear genomic control of naturally occurring variation in mitochondrial function in Drosophila melanogaster
P Jumbo-Lucioni, S Bu, ST Harbison, JC Slaughter… - BMC genomics, 2012 - Springer
Background Mitochondria are organelles found in nearly all eukaryotic cells that play a
crucial role in cellular survival and function. Mitochondrial function is under the control of …
crucial role in cellular survival and function. Mitochondrial function is under the control of …
High frequency of rare variants with a moderate-to-high predicted biological effect in protocadherin genes of extremely obese
ECM Mariman, FG Bouwman, EEJG Aller… - Genes & nutrition, 2014 - Springer
Relatively rare variants with a moderate-to-high biological effect may contribute to the
genetic predisposition of common disorders. To investigate this for obesity, we performed …
genetic predisposition of common disorders. To investigate this for obesity, we performed …
Obesity genes: so close and yet so far...
Little is known about genetic variants that predispose individuals toward leanness or
fatness. This minireview highlights recent advances in the study of human populations …
fatness. This minireview highlights recent advances in the study of human populations …
Association of the Laminin, Alpha 5 (LAMA5) rs4925386 with height and longevity in an elderly population from Southern Italy
Studies in animal models and humans suggest that reduced growth and adult stature are
associated with lifespan extension. Moreover, epidemiological studies reported a positive …
associated with lifespan extension. Moreover, epidemiological studies reported a positive …
Association of a common LAMA5 variant with anthropometric and metabolic traits in an Italian cohort of healthy elderly subjects
Laminins are large heterotrimeric glycoproteins found in basement membranes where they
play an essential role in cell-matrix adhesion, migration, growth, and differentiation of …
play an essential role in cell-matrix adhesion, migration, growth, and differentiation of …
Obesity: from animal models to human genetics to practical applications
CH Warden, JS Fisler - Progress in Molecular Biology and Translational …, 2010 - Elsevier
Although many animal models are used in genetic studies, the mouse is most common.
Analysis of single-gene mutations, linkage analysis in crossbred strains, and gene targeting …
Analysis of single-gene mutations, linkage analysis in crossbred strains, and gene targeting …